LC-2/ad

94072247, human lung, Epithelial

• Sinonimo/i: LC-2/ad Cells
• Codice UNSPSC: 41106514

Proprietà

• product name: LC-2/ad, 94072247
• Origine biologica: human lung
• Modalità di accrescimento: Adherent
• Cariotipo: Modal No 53-56
• Morfologia: Epithelial
• Prodotti: alpha-1-anti-trypsin
• Recettori: Not specified
• tecniche: cell culture | mammalian: suitable
• Malattie correlate: cancer
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −196°C

Descrizione

Origine della linea cellulare

Human lung adenocarcinoma

Descrizione della linea cellulare

Established from the pleural effusion of a pulmonary adenocarcinoma in a 51 year-old Japanese female. LC-2/ad cells exhibit an epithelial appearance and a tendency to form small domes. Immunocytochemically the cells are positive for CEA and cytokeratins, including cytokeratin No.18. LC-2/ad produces at least two functionally active trypsin inhibitors together with several proteinases in vitro.

Applicazioni

LC-2/ad has been used to study the ability of RXDX-105 as a therapy for cancers which are affected by RET (proto-oncogene tyrosine-protein kinase receptor) changes.

Terreno di coltura

RPMI 1640:HAMS F12 (1:1) + 2mM Glutamine + 10% Foetal Bovine Serum (FBS)

Mantenimento delle subcolture

Split confluent cultures 1:2-1:4 ie seeding at 2-5 x 10,000 cells/cm² using 0.25% trypsin or trypsin/ EDTA ; 5%CO₂; 37°C

Altre note

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