479M-9

MDM2 (IF2) Mouse Monoclonal Antibody

• Sinonimo/i: Mouse double minute protein 2
• Codice UNSPSC: 12352203

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100; 500
• Coniugato: unconjugated
• Forma dell’anticorpo: culture supernatant
• Tipo di anticorpo: primary antibodies
• Clone: IF2, monoclonal
• Descrizione: For In Vitro Diagnostic Use in Select Regions
• Forma fisica: buffered aqueous solution
• Reattività contro le specie: human
• Confezionamento: vial of 0.1 mL concentrate (479M-94); vial of 0.1 mL concentrate Research Use Only (479M-94-RUO); vial of 0.5 mL concentrate (479M-95); vial of 1.0 mL concentrate (479M-96); vial of 1.0 mL concentrate Research Use Only (479M-96-RUO); vial of 1.0 mL pre-dilute Research Use Only (479M-97-RUO); vial of 1.0 mL pre-dilute ready-to-use (479M-97); vial of 7.0 mL pre-dilute ready-to-use (479M-98); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (479M-98-RUO)
• Produttore/marchio commerciale: Cell Marque^™
• tecniche: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)
• Isotipo: IgG
• Controllo: dedifferentiated liposarcoma, well-differentiated liposarcoma
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• Visualizzazione: nuclear

Descrizione

Descrizione generale

Mouse double minute protein 2 (MDM2) is a gene encoded on the 12q13-14 chromosomal sequence.1-5 It encodes for a 483 amino acid residue protein which binds to the amino-terminal transcription region of p53.^2,5 MDM2 has been shown to negatively regulate the tumor-suppressor activity of p53 by three mechanisms: Blocking p53 transcription, binding to p53 causing it to be exported from the nucleus, and accelerating the destruction of p53.¹ MDM2 up-regulation has been shown in liposarcoma while being absent in lipoma.^2,4 Therefore, anti-MDM2 has been demonstrated to be a potentially useful tool in distinguishing well-differentiated liposarcoma (atypical lipomatous tumor) from lipoma, with the neoplastic cells positive in the former lesion and negative in lipoma.^2,4

Qualità

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota sulla preparazione

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Altre note

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Note legali

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany