451M-1

h-Caldesmon (hHCD) Mouse Monoclonal Antibody

• Codice UNSPSC: 12352203

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100; 500
• Coniugato: unconjugated
• Forma dell’anticorpo: diluted ascites fluid
• Tipo di anticorpo: primary antibodies
• Clone: hHCD, monoclonal
• Descrizione: For In Vitro Diagnostic Use in Select Regions
• Forma fisica: buffered aqueous solution
• Reattività contro le specie: human
• Confezionamento: vial of 0.1 mL concentrate (451M-14); vial of 0.1 mL concentrate Research Use Only (451M-14-RUO); vial of 0.5 mL concentrate (451M-15); vial of 1.0 mL concentrate (451M-16); vial of 1.0 mL concentrate Research Use Only (451M-16-RUO); vial of 1.0 mL pre-dilute Research Use Only (451M-17-RUO); vial of 1.0 mL pre-dilute ready-to-use (451M-17); vial of 7.0 mL pre-dilute ready-to-use (451M-18); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (451M-18-RUO)
• Produttore/marchio commerciale: Cell Marque^™
• tecniche: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 (concentrated)
• Isotipo: IgG1
• Controllo: bladder, colon, leiomyoma, smooth muscle tumors, stomach
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• Visualizzazione: cytoplasmic

Descrizione

Descrizione generale

Caldesmon is a protein that facilitates the regulation of cellular contraction through complexing with calmodulin, tropomyosin, and actin. Its high molecular weight isoform (h-caldesmon) has been identified to have restricted expression in visceral and vascular smooth muscle cells. In particular, strong expression of h-caldesmon has been observed in non-neoplastic uterine myometrium while being entirely absent in the endometrial layer. In spindle cell tumor pathology, overlapping immunohistochemical staining profiles between smooth muscle cells and myofibroblastic cells has not allowed for reliable identification of true smooth muscle tumors. Immunohistochemical detection of h-caldesmon has been demonstrated to aid in the distinguishing smooth muscle tumors, such as leiomyoma and leiomyosarcoma from myofibroblastic lesions, such as inflammatory myofibroblastic tumors and fibromatoses.

Qualità

IVD

IVD

IVD

RUO

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota sulla preparazione

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Altre note

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Note legali

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2