290R-1

MUC1 (EP85) Rabbit Monoclonal Primary Antibody

• Sinonimo/i: Mucin 1
• Codice UNSPSC: 12352203

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100; 500
• Coniugato: unconjugated
• Forma dell’anticorpo: culture supernatant
• Tipo di anticorpo: primary antibodies
• Clone: EP85, monoclonal
• Descrizione: For In Vitro Diagnostic Use in Select Regions
• Forma fisica: buffered aqueous solution
• Reattività contro le specie: human
• Confezionamento: vial of 0.1 mL concentrate (290R-14); vial of 0.1 mL concentrate Research Use Only (290R-14-RUO); vial of 0.5 mL concentrate (290R-15); vial of 1.0 mL concentrate (290R-16); vial of 1.0 mL concentrate Research Use Only (290R-16-RUO); vial of 1.0 mL pre-dilute Research Use Only (290R-17-RUO); vial of 1.0 mL pre-dilute ready-to-use (290R-17); vial of 7.0 mL pre-dilute ready-to-use (290R-18); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (290R-18-RUO)
• Produttore/marchio commerciale: Cell Marque^™
• tecniche: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)
• Isotipo: IgG
• Controllo: breast, colon (and Associated adenocarcinomas)
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• Visualizzazione: cytoplasmic
• Informazioni sul gene: human ... MUC1(4582)

Descrizione

Descrizione generale

Mucin 1 (MUC1) is a transmembrane glycoprotein that protects epithelial cells from injury caused by external stimuli. In addition to this role, MUC1 is involved in cell-cell adhesion, proliferation, motility, invasion and survival. In epithelial cells, MUC1 expression is regulated by binding of TNFα to TNFR1 and activation of the NFαB pathway. In human skin, MUC1 is not expressed in normal epidermis but rather in pre-malignant and malignant conditions. MUC1 has also been expressed in the epidermis of psoriatic plaques of biopsies from patients diagnosed with psoriasis vulgaris. MUC1, in addition to being localized at the apical surface of some suprabasal keratinocytes, is also localized over the entire cell surface of some of these cells and some basal keratinocytes. Conversely, no MUC1 immunoreactivity is typically detected in the epidermis of normal skin. Reactive gastropathy is the second most common diagnosis made on gastric biopsies. Increased epithelial proliferation and modifications of epithelial cytokeratin profile, distinct from those of Helicobacter pylori gastritis, have been previously reported. Loss of MUC1, either patchy or complete, was noted in 67% of the cases. The overexpression of MUC1 was found in 78% of papillary thyroid carcinomas (PTC). Multivariate analysis has shown a strong association of MUC1 expression with the presence of the BRAF (V600E) mutation and lymph node metastasis in PTC. Lymph node metastasis was the most important risk factor of relapse. In a study of thymic epithelial tumors, MUC1 was closely associated with VEGF, p53 and micro-vessel density (MVD). A 94% positive rate of MUC1 expression in thymic carcinomas and 0% in type B3 thymomas, demonstrated a significant difference. The expression of MUC1 was closely related to the grade of malignancy in thymic epithelial tumors. Positive expression of MUC1 was significantly associated with poor outcome in this disease. MUC1 may be useful marker for differentiating thymic carcinoma from type B3 thymoma.⁵

Qualità

IVD

IVD

IVD

RUO

Linkage

MUC1 Positive Control Slides, Product No. 290S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota sulla preparazione

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Altre note

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Note legali

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable