61188

Losartan Potassium

• Sinonimo/i: 2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol
• Formula empirica (notazione di Hill): C₂₂H₂₂ClKN₆O
• Numero CAS: 124750-99-8
• Peso molecolare: 461.00
• Beilstein: 5845770
• Numero MDL: MFCD02092704
• Codice UNSPSC: 41116107
• ID PubChem: 329759382
• NACRES: NA.24

Proprietà

• Forma fisica: powder or crystals
• Livello qualitativo: 200
• Durata: limited shelf life, expiry date on the label
• tecniche: HPLC: suitable; gas chromatography (GC): suitable
• Impurezze: ≤0.5% water
• applicazioni: forensics and toxicology; pharmaceutical (small molecule); veterinary
• Stringa SMILE: CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K]
• InChI: 1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1; OXCMYAYHXIHQOA-UHFFFAOYSA-N
• Informazioni sul gene: human ... AGTR1(185)

Descrizione

Descrizione generale

Losartan potassium has long lasting effects, and its efficacy is generally increased, when combined with the diuretic co-active hydrochlorothiazide.

Losartan potassium is an antihypertensive drug that is found to be an angiotensin II receptor type 1 blocker. It finds applications in reducing mechanical stress thereby having a control over the condition of cardiac hypertrophy.

Applicazioni

Losartan potassium may be used as an analytical reference standard for the quantification of the analyte in the following:

• Pharmaceutical formulations using reversed-phase high-performance liquid chromatography and UV-spectrophotometric techniques.
• Rat plasma using liquid chromatography–tandem mass spectrometry (LC–MS/MS) technique.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Azioni biochim/fisiol

Losartan potassium is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan potassium is used for treatment of hypertension.

Prodotti consigliati

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Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)