MABC119

Anti-Rab7A, clone 5G8.1 Antibody

clone 5G8.1, 0.5 mg/mL, from mouse

• Sinonimo/i: Ras-related protein Rab-7a
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 5G8.1, monoclonal
• Reattività contro le specie: human
• Concentrazione: 0.5 mg/mL
• tecniche: immunohistochemistry: suitable; western blot: suitable
• Isotipo: IgG2bκ
• N° accesso NCBI: NP_004628
• N° accesso UniProt: P51149
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... RAB7A(7879)

Descrizione

Descrizione generale

Ras-related protein Rab-7A (Rab7A, RAB7) is a small intracellular protein typically associated with cytoplasmic vesicles, phagosomes, and endosomes and is expressed in most cells but particularly high in muscle. It plays an important role in regulating the endo-lysosomal trafficking of proteins as well as in the endosomal trapping of pathogens and viruses. Besides endosome-lysosome trafficking, Rab7A functions in a variety of other critical cellular processes including nutrient uptake, growth factor mediated growth, neurotrophin transport, lipid transport, lysosome and phagosome maturation and development, as well as pathogen and virus innate immunity functions. RAB7A interacts with a number of other proteins within the cell, some important in endosome trafficking like RILP (Rab-interacting lysosomal protein) and CHM (Rab escort protein 1) others like RAC1 have a more pleiotropic impact and are part of many cellular processes, including the cell cycle, cell-cell adhesion, cytoskeletal motility, and cellular differentiation.

Immunogeno

GST-tagged recombinant protein corresponding to human Rab7A.

Applicazioni

Detect Rab7A using this Anti-Rab7A antibody, clone 5G8.1 validated for use in western blotting & IHC.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Rab7A in human breast cancer and human cardiac myocytes and lymphocytes in human heart tissue.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Qualità

Evaluated by Western Blotting in SK-MEL28 cell lysate.

Western Blotting Analysis: A 1:2,000 dilution of this antibody detected Rab7A in 10 µg of SK-MEL28 cell lysate.

Descrizione del bersaglio

~23 kDa observed

Stato fisico

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable