567310-M

SKF-96365, Hydrochloride

Inhibits receptor-mediated Ca²⁺ entry in activated platelets, neutrophils, and endothelial cells at concentrations that do not affect internal Ca²⁺ release.

• Sinonimo/i: SKF-96365, Hydrochloride, 1-[β-[3-(4-Methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole, HCl
• Formula empirica (notazione di Hill): C₂₂H₂₆N₂O₃ · xHCl
• Numero CAS: 130495-35-1
• Peso molecolare: 366.45 (free base basis)
• Numero MDL: MFCD00236407
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (TLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze
• Colore: white
• Solubilità: water: 2 mg/mL
• Temperatura di conservazione: 10-30°C
• InChI: 1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4,15-16H2,1-2H3;1H; FWLPKVQUECFKSW-UHFFFAOYSA-N

Descrizione

Descrizione generale

Inhibits receptor-mediated Ca²⁺ entry in activated platelets, neutrophils, and endothelial cells at concentrations that do not affect internal Ca²⁺ release. Also inhibits voltage-gated Ca²⁺ entry in excitable cells. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.

Inhibits receptor-mediated Ca²⁺ entry in stimulated platelets (IC₅₀ = 8-12 µM in intact platelets), neutrophils, and endothelial cells (IC₅₀ = 30 µM for human endothelial cells) at concentrations that do not affect internal Ca²⁺ release. Also inhibits voltage-gated Ca²⁺ entry in excitable cells. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.

Azioni biochim/fisiol

Primary Target
Inhibits receptor-mediated Ca2+ entry

Attenzione

Toxicity: Irritant (B)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Altre note

Leung, Y.-M., et al. 1996. Biochem. Pharmacol.51, 605.
Schwartz, G., et al. 1994. Cell Calcium15, 45.
Cabello, O.A. and Schilling, W.P. 1993. Biochem. J. 295, 357.
Graier, W.F., et al. 1992. Biochem. Biophys. Res. Commun. 186, 1539.
Blayney, L.M., et al. 1991. Biochem. J. 273, 803.
Fasolato, C., et al. 1990. J. Biol. Chem. 265, 20351.
Merritt, J.E., et al. 1990. Biochem. J.271, 515.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable