341209

EUK-8

A synthetic salen-manganese complex with high superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities.

• Sinonimo/i: EUK-8
• Formula empirica (notazione di Hill): C₁₆H₁₄ClMnN₂O₂
• Numero CAS: 53177-12-1
• Peso molecolare: 356.69
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥90% (elemental analysis)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: dark brown
• Solubilità: DMSO: 20 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C

Descrizione

Descrizione generale

A synthetic salen-manganese complex with high superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities. Shown to have protective effects in numerous models for disease processes associated with oxidative stress, including inflammation, cardiovascular diseases, acute critical illness, autoimmune diseases, and neurological disorders. Useful in preventing cardiac damage caused by ischemic reperfusion. Also prevents β-amyloid peptide (Aβ)-induced free radical formation and lipid peroxidation. Imparts protection against Aβ₄₀ and Aβ₄₂ toxicity in hippocampal cultures.

A synthetic salen-manganese complex with high superoxide dismutase (SOD), catalase, and oxyradical scavenger activities. Shown to have protective effects in numerous models for disease processes associated with oxidative stress, including inflammation, cardiovascular diseases, acute critical illness, autoimmune diseases, and neurological disorders. Useful in preventing cardiac damage caused by ischemic reperfusion. Also prevents β-amyloid peptide (Aβ)-induced free radical formation and lipid peroxidation and imparts protection against Aβ₄₀ and Aβ₄₂ toxicity in hippocampal cultures.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
Superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities

Product does not compete with ATP.

Reversible: no

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.

Altre note

Colparet, E. E. and Lefebure, R. A. 2000. Br. J. Pharmacol.130, 359.
Brandier, C., et al. 1997. J. Vasc. Res. 34, 49.
Doctrow, S.R., et al. 1997. Adv. Pharmacol. 38, 247.
Bruce, A.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 2312.
Pucheu, S., et al. 1996. Cardiovasc. Drug Ther. 10, 331.
Baudry, M., et al. 1993. Biochem. Biophys. Res. Commun. 192, 964.

Note legali

Not available for sale in Africa, Australia, Great Britain, Europe, Latvia, New Zealand, and the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2