09-827

Anti-HDAC11 Antibody

from rabbit, purified by affinity chromatography

• Sinonimo/i: histone deacetylase 11
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Purificato mediante: affinity chromatography
• Reattività contro le specie: human, mouse, rat
• tecniche: western blot: suitable
• N° accesso NCBI: NP_079103.2
• N° accesso UniProt: Q96DB2
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... HDAC11(79885) ; mouse ... Hdac11(232232) ; rat ... Hdac11(297453)

Descrizione

Descrizione generale

HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation is a marker for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.

Specificità

This antibody recognizes HDAC11.

Immunogeno

Epitope: Amino Acid: 228-246

Linear Peptide corresponding to human HDAC11 at amino acids 228-246.

Applicazioni

Anti-HDAC11 Antibody is a Rabbit Polyclonal Antibody for detection of HDAC11 also known as histone deacetylase 11 & has been validated in WB.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Histone Modifying Proteins

Cell Cycle, DNA Replication & Repair

Western Blot (SNAP ID) Analysis: 0.5 µg/ml from a representative lot detected HDAC11 on 10 µg of human brain tissue lysate.

Qualità

Evaluated by Western Blot in human brain tissue lysate.

Western Blot Analysis: 0.05 µg/ml of this antibody detected HDAC11 on 10 µg of human brain tissue lysate.

Descrizione del bersaglio

39 kDa

Stato fisico

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Risultati analitici

Control
Human brain tissue lysate

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable