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540056

Sigma-Aldrich

(R)-(−)-3-Chloro-1,2-propanediol

97%, optical purity ee: 98% (GLC)

Sinonimo/i:

(R)-α-Glycerol chlorohydrin

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About This Item

Formula condensata:
ClCH2CH(OH)CH2OH
Numero CAS:
57090-45-6
Peso molecolare:
110.54
Beilstein:
2202928
Numero MDL:
MFCD00135169
Codice UNSPSC:
12352101
ID PubChem:
24878435
NACRES:
NA.22

Tensione di vapore

0.04 mmHg ( 25 °C)

Saggio

97%

Attività ottica

[α]20/D −1°, neat

Purezza ottica

ee: 98% (GLC)

Indice di rifrazione

n20/D 1.48 (lit.)

P. eboll.

213 °C (lit.)

Densità

1.321 g/mL at 20 °C (lit.)

Stringa SMILE

OC[C@@H](O)CCl

InChI

1S/C3H7ClO2/c4-1-3(6)2-5/h3,5-6H,1-2H2/t3-/m0/s1
SSZWWUDQMAHNAQ-VKHMYHEASA-N

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Categorie correlate

Note legali

Manufactured under license by Sterling Pharma Solutions Limited, using Jacobsen HKR technology.

Avvertenze

Danger

Classi di pericolo

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Carc. 2 - Eye Dam. 1 - Met. Corr. 1 - Repr. 1B - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 1 Oral

Organi bersaglio

Kidney

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

275.0 °F - closed cup

Punto d’infiammabilità (°C)

135 °C - closed cup

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificati d'analisi (COA)

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Sigma-Aldrich

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Sigma-Aldrich

P0378

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Colin L Willis
Methods in molecular biology (Clifton, N.J.), 814, 515-529 (2011-12-07)
The goal of this chapter is to highlight methods used to demonstrate in vivo changes in astrocyte expression at the blood-brain barrier (BBB). Loss of BBB integrity is seen in many acute and chronic disease conditions. However, despite the importance
Ching-Yu Lin et al.
Reproductive toxicology (Elmsford, N.Y.), 28(1), 75-80 (2009-06-06)
Sperm ATP is derived primarily from either glycolysis or mitochondrial oxidative phosphorylation. In the present studies, (1)H NMR spectroscopy was used to characterize the metabolite profile in primate sperm treated either with alpha-chlorohydrin (ACH), a known inhibitor of sperm glycolysis
K Yamazaki et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 30(1), 52-68 (2012-08-23)
A new, direct analytical method for the determination of 3-chloro-1,2-propanediol fatty acid esters (3-MCPD esters) was developed. The targeted 3-MCPD esters included five types of monoester and 25 [corrected] types of diester. Samples (oils and fats) were dissolved in a
Shuwu Xie et al.
Reproductive biology and endocrinology : RB&E, 8, 37-37 (2010-04-23)
As one of the chlorinated antifertility compounds, alpha-chlorohydrin (ACH) can inhibit glyceraldehyde-3-phosphate dehydrogenase (G3PDH) activity in epididymal sperm and affect sperm energy metabolism, maturation and fertilization, eventually leading to male infertility. Further studies demonstrated that the inhibitory effect of ACH
Nithar Ranjan Madhu et al.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 30(2), 93-102 (2011-10-05)
To examine the effects of α-chlorohydrin on testis and cauda epididymis in the male house rat (Rattus rattus), 24 adult male rats were segregated into two groups. Group I rats were force-fed daily by intragastric intubation with α-chlorohydrin at a
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