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Merck

ABAT

4-aminobutyrate aminotransferase

Sinonimi:
GABA-AT, GABAT, NPD009
Specie:
Human ABAT (18), Mouse Abat (268860), Rat Abat (81632), Zebrafish abat (378968), cow ABAT (280969), Horse ABAT (100051470), domestic cat ABAT (101089064), dog ABAT (479856), chicken ABAT (416642), naked mole-rat Abat (101712584) ...Più
ID UniProtKB:
P80404, A8K386, Q16260, Q8N5W2, Q96BG2, Q99800
ID gene:
  • Human(18) Summary: 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(268860) 4-aminobutyrate aminotransferase
  • Rat(81632) 4-aminobutyrate aminotransferase
  • Zebrafish(378968) 4-aminobutyrate aminotransferase
  • cow(280969) 4-aminobutyrate aminotransferase
  • Horse(100051470) 4-aminobutyrate aminotransferase
  • domestic cat(101089064) 4-aminobutyrate aminotransferase
  • dog(479856) 4-aminobutyrate aminotransferase
  • chicken(416642) 4-aminobutyrate aminotransferase
  • naked mole-rat(101712584) 4-aminobutyrate aminotransferase
  • domestic guinea pig(100725419) 4-aminobutyrate aminotransferase
  • Goat(100861058) 4-aminobutyrate aminotransferase
  • sheep(101105462) 4-aminobutyrate aminotransferase

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Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
HPA041690
Anti-ABAT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry
western blot
HPA041528
Anti-ABAT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry
western blot
SAB2100006
Anti-ABAT antibody produced in rabbit, affinity isolated antibody,
Reattività con
bovine, dog, goat, guinea pig, human, mouse, rabbit, rat
Applicazione
western blot

Small Molecule - Inhibitor

N° Catalogo
Descrizione
Specie
V-022
Vigabatrin solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Specie
human
1712001
Vigabatrin, United States Pharmacopeia (USP) Reference Standard,
Specie
human
BP563
Vigabatrin, British Pharmacopoeia (BP) Reference Standard,
Specie
human
Y0001400
Vigabatrin, European Pharmacopoeia (EP) Reference Standard,
Specie
human
V8261
(±)-Vigabatrin, ,
Specie
human

esiRNA

N° Catalogo
Descrizione
Specie
EMU217131
MISSION® esiRNA, targeting mouse Abat,
Specie
mouse
EHU001161
MISSION® esiRNA, targeting human ABAT,
Specie
human
EMU015101
MISSION® esiRNA, targeting mouse Abat,
Specie
mouse