- MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding.
MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017-12-03)
Ricardo L Sanz, Gino B Ferraro, Johannes Kacervosky, Charleen Salesse, Elizabeth Gowing, Luyang Hua, Isabel Rambaldi, Francois Beaubien, Kenn Holmbeck, J F Cloutier, Martin Lévesque, Keith Murai, Alyson E Fournier
PMID29196321
RÉSUMÉ
Cell-surface molecules are dynamically regulated at the synapse to assemble and disassemble adhesive contacts that are important for synaptogenesis and for tuning synaptic transmission. Metalloproteinases dynamically regulate cellular behaviors through the processing of cell surface molecules. In the present study, we evaluated the role of membrane-type metalloproteinases (MT-MMPs) in excitatory synaptogenesis. We find that MT3-MMP and MT5-MMP are broadly expressed in the mouse cerebral cortex and that MT3-MMP loss-of-function interferes with excitatory synapse development in dissociated cortical neurons and in
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