Accéder au contenu
Merck
  • LC-MS/MS methods for albendazole analysis in feed and its metabolite residues in fish fillet and a leaching study in feed after an alternative procedure for drug incorporation.

LC-MS/MS methods for albendazole analysis in feed and its metabolite residues in fish fillet and a leaching study in feed after an alternative procedure for drug incorporation.

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment (2016-12-17)
Zenaís Busatto, Agnaldo Fernando Baldo da Silva, Osvaldo de Freitas, Jonas Augusto Rizzato Paschoal
RÉSUMÉ

This paper describes the development of analytical methods for the quantification of albendazole (ABZ) in fish feed and ABZ and its main known metabolites (albendazole sulfoxide, albendazole sulfone and albendazole aminosulfone) in fish fillet employing LC-MS/MS. In order to assess the reliability of the analytical methods, evaluation was undertaken as recommended by related guides proposed by the Brazilian Ministry of Agriculture for analytical method validation. The calibration curve for ABZ quantification in feed showed adequate linearity (r > 0.99), precision (CV < 1.03%) and trueness ranging from 99% to 101%. The method for ABZ residues in fish fillet involving the QuEChERS technique for sample extraction had adequate linearity (r > 0.99) for all analytes, precision (CV < 13%) and trueness around 100%, with CCα < 122 ng g

MATÉRIAUX
Référence du produit
Marque
Description du produit

Supelco
Albendazole sulfone, VETRANAL®, analytical standard