Copper-catalyzed α-methylenation of benzylpyridines using dimethylacetamide as one-carbon source.

Copper-catalyzed α-methylenation of benzylpyridines using dimethylacetamide as one-carbon source.

Organic letters (2014-03-22)

Masaki Itoh, Koji Hirano, Tetsuya Satoh, Masahiro Miura

RÉSUMÉ

The direct α-methylenation of benzylpyridines was achieved using N,N-dimethylacetamide (DMA) as a one-carbon source under copper catalysis. An intermediary species was detected at an early stage, and a possible mechanism was proposed. Additionally, α-oxygenation and dimerization of benzylpyridines could also be performed efficiently.

MATÉRIAUX

Référence du produit

Marque

Description du produit

270555

Sigma-Aldrich

N,N-diméthylacétamide, suitable for HPLC, ≥99.9%

38840

Sigma-Aldrich

N,N-diméthylacétamide, puriss. p.a., ≥99.5% (GC)

185884

Sigma-Aldrich