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MicroRNA-375-3p Suppresses Upper Tract Urothelial Carcinoma Cell Migration and Invasion via Targeting Derlin-1.

Cancers (2022-02-26)
Jhen-Hao Jhan, Wei-Chi Hsu, Yi-Chen Lee, Wei-Ming Li, A-Mei Huang, Hui-Hui Lin, Chien-Sheng Wang, Yi-Ru Wu, Ching-Chia Li, Wen-Jeng Wu, Hung-Lung Ke
RÉSUMÉ

Little is known regarding the molecular characterization of upper tract urothelial carcinoma (UTUC). Novel therapeutic targets and prognostic predictors are imminent. In the present study, we aim to examine the oncogenic function and molecular mechanism of Derlin-1 in UTUC. Derlin-1 overexpression is significantly associated with poor prognosis in patients with UTUC. In vitro, knockdown or over-expression of Derlin-1 markedly regulated UTUC cell invasion and migration. We further discovered miR-375-3p suppresses cell invasion and migration by inversely regulating Derlin-1 and blocking EMT in UTUC cells. Taking this together, miR-375-3p functions as a tumor suppressive microRNA by directly targeting Derlin-1 and blocking epithelial-mesenchymal transition (EMT) in UTUC.

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Description du produit

Sigma-Aldrich
Anti-DERL1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Sigma-Aldrich
Anti-OCLN Mouse mAb (1G7), liquid, clone 1G7, Calbiochem®