SBPVR4
SB PREDIVEZ™ Reagent Kit for BCRP
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About This Item
Code UNSPSC :
12161503
Produits recommandés
Produit recombinant
expressed in human cells
Forme
liquid
Conditions d'expédition
dry ice
Température de stockage
−70°C
Description générale
SOLVO Biotechnology offers ready-to-use assay kits for efflux and uptake transporters. SOLVO′s PREDIVEZ Vesicular Transport Assay Kits are suitable for efflux transporter inhibition studies. The kits are designed to test the inhibitory effect of one or more test compounds on the vesicular transport of a probe substrate. In most cases a fluorescent probe substrate is included. Kits contain all reagents and solutions necessary to conduct the drug-transporter interaction assay of need.
Application
PREDIVEZ™ vesicular transport reagent Kit may be used for assessing human ATP binding cassette subfamily B member 1 (ABCB1) function and multidrug resistance-associated protein 2 (MRP2) efflux transporter function.
The PREDIVEZ Vesicular Transport Kit is a simple and powerful tool to investigate drug transporter interactions. It provides information on any interaction between the ABC transporter and the drug candidate that would affect the transport of the fluorescent or radiolabeled or cold.
PREDIVEZ vesicular transport kits contains buffers, probe substrate, and reference inhibitors needed to run vesicular transport assays (sufficient for 300 wells/kit –equivalent to existing 9-cpd PV kits). Assay protocol, calculation template, and example data file available on SOLVO website.
Transport membranes and control membranes are sold separately. This PREDIVEZ vesicular transport kit requires the transporter membranes and corresponding control membrane below:
SSB-BCRP-M-VT BCRP human membrane vesicles part number SBVT09-1EA and corresponding control membrane SB-M-CTRL part number SBCT02-1EA
SB-BCRP-HEK293-VT BCRP human membrane vesicles part number SBVT17-1EA and corresponding control membrane SB-HEK293-Mock-CTRL part number SBCT06-1EA
PREDIVEZ vesicular transport kits contains buffers, probe substrate, and reference inhibitors needed to run vesicular transport assays (sufficient for 300 wells/kit –equivalent to existing 9-cpd PV kits). Assay protocol, calculation template, and example data file available on SOLVO website.
Transport membranes and control membranes are sold separately. This PREDIVEZ vesicular transport kit requires the transporter membranes and corresponding control membrane below:
SSB-BCRP-M-VT BCRP human membrane vesicles part number SBVT09-1EA and corresponding control membrane SB-M-CTRL part number SBCT02-1EA
SB-BCRP-HEK293-VT BCRP human membrane vesicles part number SBVT17-1EA and corresponding control membrane SB-HEK293-Mock-CTRL part number SBCT06-1EA
Informations légales
PREDIVEZ is a trademark of Solvo Biotechnology
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Met. Corr. 1 - Skin Sens. 1
Code de la classe de stockage
8A - Combustible corrosive hazardous materials
Point d'éclair (°F)
188.6 °F
Point d'éclair (°C)
87 °C
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Impact of probe compound in MRP2 vesicular transport assays
Kidron H , et al.
European Journal of Pharmaceutical Sciences, 46(1-2), 100-105 (2012)
ABCB1 transports Seliciclib (R-Roscovitine), a cyclin-dependent kinase inhibitor
Rajnai Z, et al.
Drug Metabolism and Disposition, dmd-110 (2010)
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