P1319

Thyrotropin releasing hormone

≥98% (HPLC), powder

• Synonyme(s) : pGlu-His-Pro amide
• Formule empirique (notation de Hill): C₁₆H₂₂N₆O₄
• Numéro CAS: 24305-27-9
• Poids moléculaire : 362.38
• Numéro Beilstein : 770238
• Numéro CE : 246-143-4
• Numéro MDL: MFCD00038640
• Code UNSPSC : 51111800
• ID de substance PubChem : 24898185
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: human
• Pureté: ≥98% (HPLC)
• Forme: powder
• Poids mol.: 362.38
• Conditions de stockage: (Keep container tightly closed in a dry and well-ventilated place)
• Technique(s): activity assay: suitable
• Impuretés: 22.6-23.8% Nitrogen; 51.9-54.1% carbon
• Solubilité: water: 25 mg/mL, cloudy, colorless to faintly yellow
• Numéro d'accès UniProt: P20396; P21761; P34981
• Température de stockage: −20°C
• Chaîne SMILES: NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]3CCC(=O)N3
• InChI: 1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
• Clé InChI: XNSAINXGIQZQOO-SRVKXCTJSA-N
• Informations sur le gène: human ... TRH(7200) , TRHR(7201) ; mouse ... Trhr(22045)

Description

Amino Acid Sequence

Glp-His-Pro-NH2

Description générale

Research area: Cell Signaling
Thyrotropin releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone, encoded by the gene mapped to human chromosome 3q13.3-q21. TRH is expressed in a variety of organs including central nervous system (CNS) and gastrointestinal tract, prostate, pancreas, thyroid, heart.

Application

Thyrotropin-releasing hormone has been used as a media supplement to study its effects on stimulating the secretion of prolactin (PRL) from somatolactotroph GH3 cells by enzyme immunometric assay. It has also been used to study its effects on the regulation of energy homeostasis in the central nervous system (CNS) in response to essential amino-acid deprivation.

Actions biochimiques/physiologiques

Thyrotropin releasing hormone (TRH) stimulates production and secretion of thyrotropin (TSH) and prolactin from the anterior pituitary.
It also plays a vital role as a neurotransmitter and neuromodulator. Thyrotropin-releasing hormone modulates human hair follicle functions and plays a vital role in stimulating hair growth.TRH receptor activated by TRH activates various signal transduction pathways, which mediates the formation of two-second messenger molecules, inositol 1,4,5-trisphosphate, and 1,2-diacylglycerol. TRH expressed in pancreatic β cells aids in the positive regulation of insulin secretion.

Stimulates the production of thyrotropin (TSH) and its secretion from the anterior pituitary.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)