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G8146

Sigma-Aldrich

Disialoganglioside GD1b from bovine brain

~95%, lyophilized powder

Synonyme(s) :

Ganglioside GD1b, disialo

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About This Item

Numéro CAS:
19553-76-5
Numéro MDL:
MFCD00466941
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Pureté

~95%

Niveau de qualité

200

Forme

lyophilized powder

Température de stockage

−20°C

InChI

1S/C80H144N4O37/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-54(96)83-36-49(44(91)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)111-74-65(104)63(102)67(52(40-88)114-74)116-76-66(105)72(68(53(41-89)115-76)117-73-57(84-43(3)90)71(61(100)51(39-87)112-73)118-75-64(103)62(101)60(99)50(38-86)113-75)121-80(78(108)109)35-46(93)56(82)70(120-80)59(98)48(95)42-110-79(77(106)107)34-45(92)55(81)69(119-79)58(97)47(94)37-85/h30,32,44-53,55-76,85-89,91-95,97-105H,4-29,31,33-42,81-82H2,1-3H3,(H,83,96)(H,84,90)(H,106,107)(H,108,109)/b32-30+/t44?,45-,46+,47?,48?,49?,50+,51+,52-,53+,55+,56-,57+,58?,59?,60-,61-,62-,63-,64+,65-,66+,67-,68-,69+,70-,71+,72+,73-,74-,75-,76-,79-,80-/m1/s1

Clé InChI

AIUBMTQAHKTQMI-MPGPKOMUSA-N

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Amino Acid Sequence

Cer-Glc-Gal(NeuAc-NeuAc)-GalNAc-Gal

Description générale

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Actions biochimiques/physiologiques

May act as a bacterial toxin receptor (tetanus, botulinus); high levels found in gliomas and astrocytomas.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Ricardo D Lardone et al.
Journal of neurology, neurosurgery, and psychiatry, 81(6), 629-633 (2009-12-08)
Clinical severity of Guillain-Barré syndrome (GBS) is highly variable, but the immunopathological reason is unknown. The study was designed to show which antibody parameters are associated with disease severity in GBS patients with serum anti-GM1 IgG antibodies. Thirty-four GBS patients
Vivian Marino Mazucato et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 59(4), 428-440 (2011-03-18)
The role of the mast cell-specific gangliosides in the modulation of the endocytic pathway of FcεRI was investigated in RBL-2H3 cells and in the ganglioside-deficient cell lines, E5 and D1. MAb BC4, which binds to the α subunit of FcεRI
[Case report; A case of anti-GD1b antibody positive pure motor form Guillain-Barré syndrome with good response to combined IVIg and steroid therapy].
Takeshi Fujimoto et al.
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 100(6), 1651-1653 (2011-07-21)
Ana L Moyano et al.
Glycobiology, 22(12), 1768-1774 (2012-07-31)
Immunization of rabbits with bovine brain gangliosides induced an experimental neuropathy, with clinical signs resembling Guillain-Barré syndrome. All the immunized animals developed immunoglobulin G immunoreactivity to GM1 ganglioside. In a few (4 of 27) animals, an additional anti-ganglioside antibody population
Keiichiro Susuki et al.
Experimental neurology, 233(1), 534-542 (2011-12-20)
Autoantibodies against gangliosides GM1 or GD1a are associated with acute motor axonal neuropathy (AMAN) and acute motor-sensory axonal neuropathy (AMSAN), whereas antibodies to GD1b ganglioside are detected in acute sensory ataxic neuropathy (ASAN). These neuropathies have been proposed to be
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