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Documents

E1149

Estriol

Name: Estriol
Brand: SIGMA

meets USP testing specifications

Synonyme(s) :

1,3,5(10)-Estratriene-3,16α,17β-triol, 16α-Hydroxyestradiol, 3,16α,17β-Trihydroxy-1,3,5(10)-estratriene

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About This Item

Formule empirique (notation de Hill):

C₁₈H₂₄O₃

Numéro CAS:

50-27-1

Poids moléculaire :

288.38

Numéro Beilstein :

2508172

Numéro CE :

200-022-2

Numéro MDL:

MFCD00003691

Code UNSPSC :

12352212

ID de substance PubChem :

24894391

Nomenclature NACRES :

NA.21

Agence

USP/NF
meets USP testing specifications

Pf

280-282 °C (lit.)

Chaîne SMILES

C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1C[C@@H](O)[C@@H]2O

InChI

1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1

Clé InChI

PROQIPRRNZUXQM-ZXXIGWHRSA-N

Informations sur le gène

human ... SERPINA6(866)
mouse ... Esr1(13982)
rat ... Ar(24208)

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Pictogrammes

GHS08

Mention d'avertissement

Danger

Mentions de danger

H351,H360FD,H362

Conseils de prudence

P201 - P202 - P260 - P263 - P264 - P308 + P313

Classification des risques

Carc. 2 - Lact. - Repr. 1A

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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The early history of estriol.

E Diczfalusy

Journal of steroid biochemistry, 20(4B), 945-953 (1984-04-01)

The early history of estriol is reviewed with special emphasis on its isolation, identification, quantitation in tissues and body fluids and its unique biogenesis in the human feto-placental unit. The relationship to epimeric estriols and acidic estrogens and the pharmacokinetic

Fate of estrogenic hormones in wastewater and sludge treatment: A review of properties and analytical detection techniques in sludge matrix.

Hanna Hamid et al.

Water research, 46(18), 5813-5833 (2012-09-04)

Estrogenic hormones (estrone (E1), 17β-estradiol (E2), estriol (E3), 17α-ethinylestradiol (EE2)) are the major contributor to the total estrogenicity in waterways. Presence of these compounds in biosolids is also causing concern in terms of their use as soil amendment. In comparison

Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol.

Nina Sneitz et al.

Drug metabolism and disposition: the biological fate of chemicals, 41(3), 582-591 (2013-01-05)

The glucuronidation of estriol, 16-epiestriol, and 17-epiestriol by the human UDP-glucuronosyltransferases (UGTs) of subfamilies 1A, 2A, and 2B was examined. UGT1A10 is highly active in the conjugation of the 3-OH in all these estriols, whereas UGT2B7 is the most active

Review of the endometrial safety during intravaginal treatment with estriol.

G P Vooijs et al.

European journal of obstetrics, gynecology, and reproductive biology, 62(1), 101-106 (1995-09-01)

To gain more insight into whether intravaginal treatment of local urogenital complaints with the mild-acting oestrogen estriol is capable of inducing proliferation of the endometrium, the results of the clinical studies that have been published over the years have been

Hypothalamic control of energy balance: insights into the role of synaptic plasticity.

Marcelo O Dietrich et al.

Trends in neurosciences, 36(2), 65-73 (2013-01-16)

The past 20 years witnessed an enormous leap in understanding of the central regulation of whole-body energy metabolism. Genetic tools have enabled identification of the region-specific expression of peripheral metabolic hormone receptors and have identified neuronal circuits that mediate the

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