D2069

Desvenlafaxine Hydrochloride

≥98% (HPLC), powder

• Synonyme(s) : 4-[2-(Dimethylamino)-1-(1-Hydroxycyclohexyl)Ethyl]-Phenol Hydrochloride
• Formule empirique (notation de Hill): C₁₆H₂₅NO₂ · HCl
• Numéro CAS: 300827-87-6
• Poids moléculaire : 299.84
• Numéro MDL: MFCD11045287
• Code UNSPSC : 12352200
• ID de substance PubChem : 329798729
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to off-white
• Solubilité: DMSO: >20 mg/mL; H₂O: >20 mg/mL
• Auteur: Wyeth
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl.CN(C)CC(c1ccc(O)cc1)C2(O)CCCCC2
• InChI: 1S/C16H25NO2.ClH/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16;/h6-9,15,18-19H,3-5,10-12H2,1-2H3;1H
• Clé InChI: IMWPSXHIEURNKZ-UHFFFAOYSA-N

Description

Application

Desvenlafaxine hydrochloride has been used to evaluate if its occurrence in drinking water at environmental concentrations could induce neuronal gene expression.

Actions biochimiques/physiologiques

Desvenlafaxine hydrochloride is a dual SERT/NET reuptake inhibitor. It is a major active metabolite of venlafaxine (#542); brain penetrant; K_i = 40 nM and 122 nM for hSERT and hNET, respectively (weak binding at the hDAT). Inhibition of [3H]5-HT or [3H]NE uptake for the hSERT or hNET produced IC₅₀ values of 47 and 531 nM.

Desvenlafaxine hydrochloride is a psychoactive drug. Incidence of this drug in environmental samples might induce in vitro gene expression associated with neurological disorders.

Caractéristiques et avantages

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H319
• Conseils de prudence: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classification des risques: Eye Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves