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902H-0

Sigma-Aldrich

Cytokeratin 5 & 6 (D5/16B4) + TTF-1 (8G7G3/1) Mouse Monoclonal Antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

D5&16B4 + 8G7G3/1, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions (See Chart)

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

bottle of 1.0 mL predilute (902H-07)
bottle of 7.0 mL predilute (902H-08)

Isotype

IgG1

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Informations sur le gène

human ... KRT5(3852)

Description générale

Anti-Cytokeratin 5 & 6 labels greater than 90% of Eptihelioid Mesotheliomas. Anti-Cytokeratin 5 & 6 stains the cytoplasm of such cells. Anti-TTF-1 stains the nuclei in the case of lung adenocarcinomas and is negative in nearly all mesotheliomas. When the differential diagnosis seeks to distinguish between mesothelioma and adenocarcinoma of the lung, the nuclear vs. Cytoplasmic staining pattern of this cocktail can be of significant value in making the diagnosis.

Qualité


IVD
IVD
IVD
RUO

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Notes préparatoires

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Pablo A Bejarano et al.
Archives of pathology & laboratory medicine, 127(2), 193-195 (2003-02-04)
The immunohistochemical identification of thyroid transcription factor-1 (TTF-1) is regarded as the presence of a nuclear pattern of staining and is used to identify tumors of thyroid or pulmonary origin. Although there have been reports of cytoplasmic expression of TTF-1
Dongfeng Tan et al.
Human pathology, 34(6), 597-604 (2003-06-27)
Thyroid transcription factor 1 (TTF-1), a homeodomain-containing transcription factor, plays a pivotal role in lung development, cell growth, and differentiation processes. The current literature reports considerable variation in frequency of TTF-1 protein expression in human non-small cell lung cancer (NSCLC).
P M Cury et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 13(2), 107-112 (2000-03-04)
Until recently, the standard approach of most laboratories in distinguishing epithelioid pleural mesothelioma from metastatic adenocarcinoma has been a negative result from a panel of adenocarcinoma-associated antibodies. However, several "mesothelium-associated" antibodies have been proposed as useful in this situation, and
N G Ordóñez
The American journal of surgical pathology, 22(10), 1215-1221 (1998-10-20)
The immunohistochemical diagnosis of mesothelioma is commonly made by using a battery of antibodies that reacts with lung adenocarcinomas but not with epithelial mesotheliomas. Only recently have markers that are often expressed in mesotheliomas but not in adenocarcinomas been recognized.
K Y Jang et al.
Analytical and quantitative cytology and histology, 23(6), 400-404 (2002-01-05)
To estimate the utility of thyroid transcription factor-1 (TTF-1) and the combined cytokeratin 7 (CK7) and 20 (CK20) immunoprofile as a marker for identifying the primary site of metastatic adenocarcinoma in effusions of the serous cavity. Formalin-fixed, paraffin-embedded cell block
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