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Key Documents

311R-1

Sigma-Aldrich

PAX-2 (EP235) Rabbit Monoclonal Primary Antibody

clone EP235, unconjugated, Cell Marque™

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

EP235, monoclonal

Description

(For In Vitro Diagnostic Use in Select Regions (See Chart))

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

bottle of 1.0 mL predilute (311R-17)
bottle of 7.0 mL predilute (311R-18)
vial of 0.1 mL concentrate (311R-14)
vial of 0.5 mL concentrate (311R-15)
vial of 1.0 mL concentrate (311R-16)

Fabricant/nom de marque

Cell Marque™

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50

Isotype

IgG

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Informations sur le gène

human ... PAX2(5076)

Catégories apparentées

Description générale

PAX-2 is a homeogene strongly expressed during kidney development. PAX-2 gene is expressed in the metanephric mesenchyma after ureter bud induction and is a key factor for the mesenchyma-epithelium conversion. Animals transgenic for PAX-2 have severe renal abnormalities and cysts but no solid tumoral features. The oncogenic potential of the PAX gene family has been reported <em>in vitro</em> with transformation of cell cultures and <em>in vivo</em> with cell injections in nude mice. Gnarra et al. showed PAX-2 expression in renal carcinoma cell lines and underlined its potential role in cell proliferation in these lines.1 Mazal et al. demonstrated PAX-2 nuclear expression in 88% of clear cell renal cell carcinomas as well as 18% of papillary renal cell carcinoma, and 13% of chromophobe renal cell carcinomas.2 More recently, Chivukula et al. demonstrated utility in distinguishing ovarian serous papillary carcinoma (anti-PAX-2 positive) from breast carcinoma (anti-PAX-2 negative).3

Qualité


IVD
IVD
IVD
RUO

Liaison

PAX-2 Positive Control Slides, Product No. 311S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Notes préparatoires

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Consulter la Bibliothèque de documents

J R Gnarra et al.
Cancer research, 55(18), 4092-4098 (1995-09-15)
Renal cell carcinoma (RCC) is the most common malignancy in the adult kidney. Because RCC is generally thought to arise from the epithelium of the proximal tubules, the expression of Pax-2, a gene required for renal epithelium development, was examined
Peter R Mazal et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 18(4), 535-540 (2004-10-27)
Diagnostic use of antibodies against aquaporin water channel proteins and PAX-2, a nuclear transcription factor in renal development, was tested in 202 renal neoplasms, using tissue microarray technique. Immunohistochemistry for aquaporin-1, aquaporin-2, PAX-2, CD10, and cytokeratin 7 was performed on
Mamatha Chivukula et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 28(6), 570-578 (2009-10-24)
Ovarian serous papillary carcinoma, although rarely metastasizing to the breast, is often challenging based on morphology alone, particularly from the micropapillary variant of breast carcinoma. Gross cystic disease fluid protein-15, although a specific marker, can be negative in up to

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Diagnostic Immunohistochemistry Procedures

Diagnostic immunohistochemistry overview highlights its importance in cancer diagnosis and detecting infectious diseases in modern clinical pathology.

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