5.08839

Telomerase Inhibitor X, BIBR1532

• Synonyme(s) : Telomerase Inhibitor X, BIBR1532, BIBR 1532, BIBR-1532
• Formule empirique (notation de Hill): C₂₁H₁₇NO₃
• Numéro CAS: 321674-73-1
• Poids moléculaire : 331.36
• Code UNSPSC : 12352200

Propriétés

• Pureté: ≥98% (HPLC)
• Niveau de qualité: 100
• Forme: solid
• Puissance: 93 nM IC₅₀
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: off-white
• Solubilité: DMSO: 100 mg/mL
• Température de stockage: 2-8°C
• InChI: 1S/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+
• Clé InChI: PGFQXGLPJUCTOI-WYMLVPIESA-N

Description

Description générale

A cell-permeable benzoic acid based compound that acts as a selective, highly potent, non-nucleotide competitive inhibitor of the catalytic activity of telomerase (IC₅₀ = 93 nM in HeLa cells nuclear extracts). Also shown to be effective against recombinant, affinity purified telomerase. Blocks the growth and proliferation of HeLa cells (~ 20 µM) by inducing apoptosis. The inhibition appears to be more prominent in TEL patch mutant cell lines. Causes a continuous erosion of telomeres in multiple human cancer cell lines. Does not affect the activity of DNA and RNA polymerases in any significant manner.

A cell-permeable benzoic acid based compound that acts as a selective, highly potent, non-nucleotide competitive inhibitor of the catalytic activity of telomerase (IC₅₀ = 93 nM in HeLa cells nuclear extracts). Also shown to be effective against recombinant, affinity purified telomerase. Blocks the growth and proliferation of HeLa cells (~ 20 µM) by inducing apoptosis. The inhibition appears to be more prominent in TEL patch mutant cell lines. Causes a continuous erosion of telomeres in multiple human cancer cell lines. Does not affect the activity of DNA and RNA polymerases in any significant manner.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Teomerase

Reversible: yes

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Damm, K., et al. 2001. The. EMBO J.20, 6958.
Pascolo, E., et al. 2002. J. Biol. Chem.277,15566.

Nakashima, M., et al. 2013. J. Biol. Chem.288, 33171.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable