5.08148

Nefazodone Hydrochloride

• Synonyme(s) : Nefazodone Hydrochloride, 5-HT _2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone, 5-HT_2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone
• Formule empirique (notation de Hill): C₂₅H₃₂ClN₅O₂ · xHCl
• Numéro CAS: 82752-99-6
• Poids moléculaire : 470.01 (free base basis)
• Numéro MDL: MFCD00935760
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥99% (HPLC)
• Niveau de qualité: 100
• Forme: solid
• Puissance: 26 nM K_i
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: ethanol: 10 mM; DMSO: 25 mM
• Température de stockage: 2-8°C
• InChI: 1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H
• Clé InChI: DYCKFEBIOUQECE-UHFFFAOYSA-N

Description

Description générale

A potent 5-HT_2A receptor antagonist (K_d = 26 nM), with moderate affinity for the alpha1-adrenergic receptor (K_d = 48 nM) and 5-HT_1A receptor (K_d = 80 nM). Originally developed as a clinical antidepressant but discontinued in 2004, nefazodone (Serzone) still remains a specific inhibitor of certain serotonergic pathways. Nefazodone also has been reported to induce mitochondrial dysfuntion.

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Kim, J.-A. et al. 2012. Toxicol. Lett.214, 175.
Cusack, B. et al. 1994. Psychopharmacol.114, 559.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable