5.00498

HIF Inhibitor V

• Synonyme(s) : HIF Inhibitor V, Hypoxia-Inducible Factor Inhibitor V, ( E)-3-(3-(4-Adamantan-1-ylphenoxy)acrylamido)benzoic acid morpholinoethyl ester
• Formule empirique (notation de Hill): C₃₂H₃₈N₂O₅
• Numéro CAS: 1373443-16-3
• Poids moléculaire : 530.65
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥99% (HPLC)
• Niveau de qualité: 100
• Forme: powder
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: DMSO: 50 mg/mL
• Température de stockage: 2-8°C

Description

Description générale

A cell-permeable phenoxyacrylamido compound that inhibits hypoxia-induced cellular HIF-1α accumulation in a manner similar to LW6 (Cat. No. 400083) by upregulating von Hippel-Lindau tumor suppressor gene product pVHL, but with much higher potency (IC₅₀ = 120 nM vs 2.44 µM, respectively, against hypoxia-induced HRE reporter activity in HCT116 cells). Shown to suppress the mRNA levels of HIF-1 target genes in HCT116 cultures (VEGF, EPO, and MMP-9; effective conc. ≥2 µM) and effectively inhibit HUVEC tubule formation (effective conc. 2 to 5 µM) under hypoxia conditions.

A cell-permeable phenoxyacrylamido compound that inhibits hypoxia-induced cellular HIF-1α accumulation in a manner similar to LW6 (Cat. No. 400083) by upregulating Hippel-Lindau tumor suppressor gene product pVHL, but with much higher potency (IC₅₀ = 120 nM vs 2.44 µM, respectively, against hypoxia-induced HRE reporter activity in HCT116 cells). Shown to suppress HIF-1 target genes expression in HCT116 cultures and inhibit HUVEC tubule formation (effective conc. ≥2 µM) under hypoxia conditions.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Actions biochimiques/physiologiques

Cell permeable: yes

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Use only fresh DMSO for reconstitution.

Autres remarques

Naik, R., et al. 2012. J. Med. Chem.55, 10564.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable