480746-M

Neuronal Differentiation Inducer IV

A cell-permeable quinoxaline compound that is shown to induce neuronal differentiation in PC12 and rat MSC (mesenchymal stem cell) cultures with high efficiency.

• Synonyme(s) : Neuronal Differentiation Inducer IV, N-Hydroxy-2-oxo-3-(3-phenylpropyl)-1,2-dihydroquinoxaline-6-carboxamide, 2-Oxo-3-(3-phenyl-propyl)-1,2-dihydro-quinoxaline-6-carboxylic acid hydroxyamide
• Formule empirique (notation de Hill): C₁₈H₁₇N₃O₃
• Poids moléculaire : 323.35
• Code UNSPSC : 12352200

Propriétés

• Pureté: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: off-white
• Solubilité: DMSO: 25 mg/mL, pale yellow
• Température de stockage: 2-8°C

Description

Description générale

A cell-permeable quinoxaline compound that is shown to induce neuronal differentiation in PC12 and rat MSC (mesenchymal stem cell) cultures with high efficiency (>95%; 20 µM for 48 h) as determined by Nissl staining, expressions of neuronal markers and genes (β-III tubulin, NSE, Chrna2, Chrnb2, Chrm4, Foxo2, Sizn 1), as well as by whole-cell electrophysiology measurements, without any concomitant astroglial differentiation induction as indicated by the absence of GFAP (glial fibrillary acidic protein) expression.

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Kim, N.R., et al. 2009. J. Med. Chem.52, 7931.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable