203297-M

Bisindolylmaleimide IV

A potent, cell permeable, and selective inhibitor of protein kinase C (IC₅₀ = 87 nM).

• Synonyme(s) : Bisindolylmaleimide IV, Arcyriarubin A, 2,3- bis(1H-Indol-3-yl)maleimide, Ro 31-6233
• Formule empirique (notation de Hill): C₂₀H₁₃N₃O₂
• Numéro CAS: 119139-23-0
• Poids moléculaire : 327.34
• Numéro MDL: MFCD00236432
• Code UNSPSC : 12352111

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (TLC)
• Forme: powder; solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: dark orange
• Solubilité: methanol: 10 mg/mL
• Température de stockage: 2-8°C
• InChI: 1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
• Clé InChI: DQYBRTASHMYDJG-UHFFFAOYSA-N

Description

Description générale

A cell-permeable potent and selective inhibitor of protein kinase C (IC₅₀ = 87 nM) and protein kinase A (IC₅₀ = 2.7 µM).

A potent, cell permeable, and selective inhibitor of protein kinase C (IC₅₀ = 87 nM). Inhibits protein kinase A at much higher concentrations (IC₅₀ = 2.7 µM).

Actions biochimiques/physiologiques

Primary Target
PKC

Target IC₅₀: 87 nM against protein kinase C

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Fabre, S., et al. 1993. Bioorg. Med. Chem.1, 193.
Davis, P.D., et al. 1992. J. Med. Chem.35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable