04-1551

Anti-SMRT Antibody, clone 1SM-1E7

ascites fluid, clone 1SM-1E7, from mouse

• Synonyme(s) : CTG repeat protein 26, Silencing mediator of retinoic acid and thyroid hormone receptor, T3 receptor-associating factor, Thyroid-, retinoic-acid-receptor-associated corepressor, nuclear receptor co-repressor 2, silencing mediator for retinoid and thyroid
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Forme d'anticorps: ascites fluid
• Type de produit anticorps: primary antibodies
• Clone: 1SM-1E7, monoclonal
• Espèces réactives: mouse, rat, human
• Technique(s): western blot: suitable
• Isotype: IgG2aκ
• Numéro d'accès NCBI: NP_001070729.1
• Numéro d'accès UniProt: Q9Y618
• Conditions d'expédition: dry ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... NCOR2(9612) , TRAC(28755)

Description

Description générale

The Silencing mediator of retinoic acid & thyroid hormone receptor protein, commonly called the SMRT protein mediates the transcriptional repression of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription machinery. Consistent with this activity, this protein is known to form a large corepressor complex containing SIN3A/B and histone deacetylases HDAC1 and HDAC2. SMRT is also a component of the N-Cor repressor (nuclear receptor corepressor), a multi-subunit complex minimally composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. SMRT and nuclear receptor corepressor N-CoR are related transcriptional corepressors which contain two distinct domains capable of interacting with unliganded nuclear receptors to repress their basal transcriptional activity.

Spécificité

This antibody recognizes SMRT.

Application

Use Anti-SMRT Antibody, clone 1SM-1E7 (Mouse Monoclonal Antibody) validated in WB to detect SMRT also known as CTG repeat protein 26, Silencing mediator of retinoic acid & thyroid hormone receptor.

Qualité

Evaluated by Western Blot in human brain lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected SMRT on 10 µg of human brain lysate.

Description de la cible

~ 275 kDa

Forme physique

Unpurified mouse monoclonal IgG2aκ ascites with 0.05% sodium azide.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable