Accéder au contenu
Merck
Toutes les photos(2)

Key Documents

Autres documents

700086P

Avanti

DHEA sulfate

Avanti Research™ - A Croda Brand

Synonyme(s) :

DHEA sulfate; DHEA; DHEA-S; 3β-hydroxy-5-androsten-17-one 3-sulfate (sodium salt); 5-androsten-3β-ol-17-one sulfate (sodium salt Prasterone sulfate (sodium salt)

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(2)

About This Item

Formule empirique (notation de Hill):
C19H27NaO5S
Numéro CAS:
651-48-9
Poids moléculaire :
390.47
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Description

Dehydroepiandrosterone sulfate (sodium salt)

Pureté

>99% (TLC)

Forme

powder

Conditionnement

pkg of 1 × 10 mg (700086P-10mg)
pkg of 1 × 25 mg (700086P-25mg)
pkg of 1 × 50 mg (700086P-50mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand

Conditions d'expédition

dry ice

Température de stockage

−20°C

InChI

1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/t13-,14-,15-,16-,18-,19-/m0/s1

Clé InChI

CZWCKYRVOZZJNM-USOAJAOKSA-N

Description générale

DHEA sulfate is a metabolite of dehydroepiandrosterone (DHEA) produced by the addition of a sulfate group, catalyzed by the sulfotransferase enzymes SULT1A1 and SULT1E1, which also produce estrone sulfate from estrone. DHEA sulfate can also be back-converted to DHEA through the action of steroid sulfatase.
Dehydroepiandrosterone (DHEA) sulfate (DHEAS) is an adrenal steroid and is present in abundance in humans. It is the sulfate ester of DHAE and is synthesized by the adrenal glands and the gonads. DHEAS is produced in the zona reticularis.

Application

DHEA sulfate has been used:
  • as a sulfated steroid in chemotaxis assay of bone-marrow (BM) neutrophil and also to test its inhibitory effect on the Rac-specific guanine nucleotide exchange factor (Rac GEF)
  • as an internal standard in mass spectrometry
  • as a synthetic lipid standard for spiking low-density lipoprotein (LDL) samples for liquid chromatography-mass spectrometry analysis (LC-MS)

Actions biochimiques/physiologiques

Dehydroepiandrosterone (DHEA) sulfate (DHEAS) regulates the synthesis of catecholamines. It modulates neurotransmitter receptors including the γ-aminobutyric acid type A (GABAA) and the N-methyl-D -aspartate (NMDA) receptors. Low levels of DHAES in brain is observed in Alzheimer′s disease (AD) patients.

Conditionnement

5 mL Amber Glass Screw Cap Vial (700086P-10mg)
5 mL Amber Glass Screw Cap Vial (700086P-25mg)
5 mL Amber Glass Screw Cap Vial (700086P-50mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Souvent commandé avec ce produit

Réf. du produit
Description
Tarif

700087P

DHEA, Avanti Polar Lipids

Code de la classe de stockage

11 - Combustible Solids

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Ana Reis et al.
Journal of lipid research, 54(7), 1812-1824 (2013-05-15)
Lipidome profile of fluids and tissues is a growing field as the role of lipids as signaling molecules is increasingly understood, relying on an effective and representative extraction of the lipids present. A number of solvent systems suitable for lipid
Joseph S Dillon
Current drug targets. Inflammation and allergy, 4(3), 377-385 (2005-08-17)
Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) are metabolic intermediates in the production of potent androgens, estrogens and other less well-characterized steroids. DHEA(S) and closely related steroid hormones have a variety of immunological effects both in vitro and in vivo in
Marco Racchi et al.
CNS drug reviews, 9(1), 21-40 (2003-02-22)
The physiological role of dehydroepiandrosterone (DHEA) and its sulphated ester DHEA(S) has been studied for nearly 2 decades and still eludes final clarification. The major interest in DHEA derives from its unique pattern of activity. Its levels exhibit a dramatic
Kuei-Fang Chung et al.
Molecular and cellular endocrinology, 336(1-2), 141-148 (2010-12-07)
Dehydroepiandrosterone producing adrenocortical zona reticularis and the adrenal medulla are in direct contact and are highly intermingled in many species. This results in potentially strong paracrine influences of high local dehydroepiandrosterone concentrations on the adrenal medulla. Dehydroepiandrosterone has neuroprotective properties
P Ebeling et al.
Lancet (London, England), 343(8911), 1479-1481 (1994-06-11)
Dehydroepiandrosterone (DHEA), with its sulphate conjugate (DHEAS), is the most abundant steroid hormone in the circulation but its physiological importance is unclear. We propose that DHEA has either oestrogen-like or androgen-like effects depending on the hormonal milieu. In premenopausal women
Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique