934275

Pomalidomide-piperazine

≥ 95.0%

• Synonyme(s) : 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-(1-piperazinyl)-2-(2,6-Dioxopiperidin-3-yl)-4-(piperazin-1-yl)isoindole-1,3-dione
• Formule empirique (notation de Hill): C₁₇H₁₈N₄O₄
• Numéro CAS: 2154342-57-9
• Poids moléculaire : 342.35
• Numéro MDL: MFCD32898791
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥ 95.0%
• Forme: powder or crystals
• Couleur: faint yellow to dark yellow
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C1NC(=O)C(N2C(=O)C3=CC=CC(=C3C2=O)N4CCNCC4)CC1

Description

Application

A functionalized cereblon ligand for development of Pomalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination; and a basic building block for making protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Autres remarques

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Informations légales

PROTAC^® is a registered trademark of Arvinas Operations; Inc.; and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H360D
• Conseils de prudence: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable