Toutes les photos(2)

Documents

142662

Chlorosulfonyl isocyanate

Name: Chlorosulfonyl isocyanate
Brand: ALDRICH

98%

Synonyme(s) :

CSI

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme

Toutes les photos(2)

About This Item

Formule linéaire :

ClSO₂NCO

Numéro CAS:

1189-71-5

Poids moléculaire :

141.53

Numéro Beilstein :

1237247

Numéro CE :

214-715-2

Numéro MDL:

MFCD00011608

Code UNSPSC :

12352100

ID de substance PubChem :

24848531

Nomenclature NACRES :

NA.22

Pression de vapeur

5.57 psi ( 20 °C)

Niveau de qualité

200

Pureté

98%

Forme

liquid

Indice de réfraction

n20/D 1.447 (lit.)

Point d'ébullition

107 °C (lit.)

Pf

−44 °C (lit.)

Densité

1.626 g/mL at 25 °C (lit.)

Température de stockage

2-8°C

Chaîne SMILES

ClS(=O)(=O)N=C=O

InChI

1S/CClNO3S/c2-7(5,6)3-1-4

Clé InChI

WRJWRGBVPUUDLA-UHFFFAOYSA-N

Informations sur le gène

human ... ABCB1(5243) , FPR1(2357)

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Description générale

Chlorosulfonyl isocyanate is classified as an isocyanate and is widely used as a reagent in sulfonylation and carbamoylation reactions.Chlorosulfonyl isocyanate reacts with hydrocarbon alkenes via stepwise dipolar pathway to give N-chlorosulfonyl-β-lactams.

Application

Chlorosulfonyl isocyanate was used in synthesis and biochemical characterization of new class of membrane-associated glycosyltransferase inhibitors.
It is synthetically versatile reagent and was used in the preparation of amides, lactams and triazocinones.
It was employed in regio- and diastereoselective introduction of a protected amino group in synthesis of chiral, polyhydroxylated piperidines.
It was used as reagent during the synthesis of novel sulfamides.

Employed in a regio- and diastereoselective introduction of a protected amino group in a synthesis of chiral, polyhydroxylated piperidines. Generation of ureas from amino groups in a synthesis of benzimidazolones.

Pictogrammes

GHS08,GHS05,GHS07

Mention d'avertissement

Danger

Mentions de danger

H302,H314,H317,H334

Conseils de prudence

P261 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338

Classification des risques

Acute Tox. 4 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

Risques supp

EUH014

Code de la classe de stockage

8A - Combustible corrosive hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

>230.0 °F

Point d'éclair (°C)

> 110 °C

Équipement de protection individuelle

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Synthetic Communications, 22, 2729-2729 (1992)

Kinetic studies on the reaction of chlorosulfonyl isocyanate with monofluoroalkenes: experimental evidence for both stepwise and concerted mechanisms and a pre-equilibrium complex on the reaction pathway.

Dale F Shellhamer et al.

The Journal of organic chemistry, 78(2), 246-252 (2012-12-15)

Chlorosulfonyl isocyanate (CSI) is reported to react with hydrocarbon alkenes by a stepwise dipolar pathway to give N-chlorosulfonyl-β-lactams that are readily reduced to β-lactams. Substitution of a vinyl hydrogen for a vinyl fluorine changes the dynamics for reaction with CSI

Synthesis and characterization of a new class of inhibitors of membrane-associated UDP-glycosyltransferases.

P Paul et al.

The Journal of biological chemistry, 268(17), 12933-12938 (1993-06-15)

A new class of compounds designed to inhibit membrane-associated glycosyltransferases were synthesized and their biological activities were characterized in liver microsomes and human lymphoma cell lines. These inhibitors are composed of N-acyl phenylaminoalcohol derivatives linked to uridine via different spacers.

Tetrahedron Letters, 47, 129-129 (2006)

Synthetic Communications, 23, 2151-2151 (1993)

Afficher tous les articles scientifiques apparentés

Protocoles

Using UHPLC/MS (TOF) for Detection of Drugs and Metabolites in Urine Following Optimized Enzymatic Hydrolysis Conditions

To optimize hydrolysis using β-glucuronidase, factors such as incubation time, temperature, hydrolysis pH, enzyme source, and enzyme concentration must be evaluated for each glucuronide metabolite to be analyzed.

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique