Intensified & Continuous Upstream (USP) Processing

Future-proof your manufacturing strategies, reduce costs and increase facility flexibility with intensified fed-batch and perfusion processes

HomeIntegrated OfferingsBiopharma 4.0 Intensified and Continuous Upstream (USP) ProcessingUpstream Processing in the Facility of the Future

Biopharmaceutical developers and manufacturers need efficient, productive upstream processes that deliver high quality monoclonal antibodies (mAbs) and other types of recombinant proteins. Process intensification, including intensified fed-batch and perfusion processes, can future-proof their manufacturing strategies, reduce costs, and increase facility flexibility.

With a full suite of solutions designed to support the increased demands of intensified upstream processes and technical support from teams with years of experience, we can help you realize the benefits of upstream process intensification without compromising clinical milestones or speed to market.

Intensified and Continuous Upstream (USP) Processing

Seed Train Intensification

Production and Harvest Intensification

Upstream Processing in the Facility of the Future

Intensified upstream processing is just the start of the evolution to the facility of the future. Our solutions for intensified or continuous downstream technologies enable further gains in manufacturing efficiency and flexibility, in addition to supporting the transition to fully closed processing. To further support intensification efforts and transition into next-generation bioprocessing facilities, these systems also offer best-in-class process analytical technology (PAT) tools to monitor and control critical process parameters. With next-generation automation and control capabilities, such as our Bio4C ACE™ software, automation of these systems can now be achieved in a secure, intuitive, and precise manner. Smart data management systems accelerate insights and actions in your process, enabling manufacturers to make the most out of the process data collected

Related Categories

The image depicts a laboratory scene with two professionals working on a large stainless steel equipment. They are both wearing white lab coats and gloves, suggesting a sterile environment. One person is standing and appears to be handling something with purple gloves, while the other is seated. The equipment is connected to various tubes and wires, indicating its complex functionality.

Bioprocessing Cell Culture Media

With our comprehensive portfolio, you can choose from tried-and-true formulations...

Bioprocessing Mobius^® Single-Use Bioreactors

Mobius^® products and solutions can help you meet your evolving cell culture needs...

Cell Retention

Perfusion operations deliver high-density cell cultures that alleviate the burden of processing large production bioreactor...

Datasheet: Mobius^® iFlex Bioreactor
The Mobius^® iFlex Bioreactor is a scalable family of next generation high-performance single-use modular bioreactors for fed-batch and perfusion processes, ranging from 50 L to 2000 L, and suitable for process development and commercial manufacturing.
Datasheet: Mobius^® Breez Microbioreactor
The Mobius^® Breez Microbioreactor is a 2 mL automated single-use perfusion cell culture platform designed to support gentle, adaptable, and reproducible cell processes. The system is capable of accelerating a range of applications such as cell line development, media screening and optimization, and early process development.