SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
Synonymes:
NCX1
Espèce(s):
Human SLC8A1 (6546), Mouse Slc8a1 (20541), Rat Slc8a1 (29715), Domestic Rabbit SLC8A1 (100328570), naked mole-rat Slc8a1 (101711105), domestic guinea pig Slc8a1 (100135620), cow SLC8A1 (337925), sheep SLC8A1 (101116716), chicken SLC8A1 (395760), dog SLC8A1 (475738) ...Plus
ID UniProtKB:
ID du gène:
- Human(6546) Summary: In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]
- Mouse(20541) solute carrier family 8 (sodium/calcium exchanger), member 1
- Rat(29715) solute carrier family 8 (sodium/calcium exchanger), member 1
- Domestic Rabbit(100328570) solute carrier family 8 (sodium/calcium exchanger), member 1
- naked mole-rat(101711105) solute carrier family 8 (sodium/calcium exchanger), member 1
- domestic guinea pig(100135620) solute carrier family 8 (sodium/calcium exchanger), member 1
- cow(337925) solute carrier family 8 (sodium/calcium exchanger), member 1
- sheep(101116716) solute carrier family 8 (sodium/calcium exchanger), member 1
- chicken(395760) solute carrier family 8 (sodium/calcium exchanger), member 1
- dog(475738) solute carrier family 8 (sodium/calcium exchanger), member 1
- Horse(100034157) solute carrier family 8 (sodium/calcium exchanger), member 1
- domestic cat(493807) solute carrier family 8 (sodium/calcium exchanger), member 1
- dog(493808) solute carrier family 8 (sodium/calcium exchanger), member 1
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Antibodies
Référence du produit
Description
Espèces réactives
Application
ANTI-SLC8A1 (CENTER) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Espèces réactives
human, mouse
Application
flow cytometry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Sodium-Calcium Exchanger 1 Antibody, Chemicon®, from rabbit,
Espèces réactives
rat
Application
ELISA
western blot
western blot
Monoclonal Anti-Na+/Ca2+ Exchanger antibody produced in mouse, clone C2C12,
Espèces réactives
canine, guinea pig, human, rabbit, rat
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-SLC8A1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence