PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
Synonymes:
CSNB3, CSNBAD2, PDEB, RP40, rd1
Espèce(s):
Human PDE6B (5158), Mouse Pde6b (18587), Rat Pde6b (289878), domestic guinea pig Pde6b (100721588), naked mole-rat Pde6b (101705017), cow PDE6B (281974), sheep PDE6B (101108490), Zebrafish pde6b (559332), domestic cat PDE6B (101095012), dog PDE6B (399653)
ID UniProtKB:
ID du gène:
- Human(5158) Summary: Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
- Mouse(18587) phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
- Rat(289878) phosphodiesterase 6B, cGMP-specific, rod, beta
- domestic guinea pig(100721588) phosphodiesterase 6B, cGMP-specific, rod, beta
- naked mole-rat(101705017) phosphodiesterase 6B, cGMP-specific, rod, beta
- cow(281974) phosphodiesterase 6B, cGMP-specific, rod, beta
- sheep(101108490) phosphodiesterase 6B, cGMP-specific, rod, beta
- Zebrafish(559332) phosphodiesterase 6B, cGMP-specific, rod, beta
- domestic cat(101095012) phosphodiesterase 6B, cGMP-specific, rod, beta
- dog(399653) phosphodiesterase 6B, cGMP-specific, rod, beta
- chicken(395092) phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness 3, autosomal dominant)
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Antibodies
Product Number
Description
Espèces réactives
Application
Anti-PDE6B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-PDE6B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunohistochemistry
Small Molecule - Inhibitor
Product Number
Description
Espèce(s)
Dipyridamole for peak identification, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human