MDM2
MDM2 oncogene, E3 ubiquitin protein ligase
Synonymes:
ACTFS, HDMX, hdm2
Espèce(s):
Human MDM2 (4193), Mouse Mdm2 (17246), Rat Mdm2 (314856), Zebrafish mdm2 (30637), dog MDM2 (403693), domestic cat MDM2 (493939), cow MDM2 (540378), Horse MDM2 (100033891), chicken MDM2 (395609), domestic guinea pig Mdm2 (100724684) ...Plus
ID UniProtKB:
ID du gène:
- Human(4193) Summary: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
- Mouse(17246) transformed mouse 3T3 cell double minute 2
- Rat(314856) p53 E3 ubiquitin protein ligase
- Zebrafish(30637) transformed 3T3 cell double minute 2 homolog (mouse)
- dog(403693) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- domestic cat(493939) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- cow(540378) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- Horse(100033891) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- chicken(395609) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- domestic guinea pig(100724684) MDM2 oncogene, E3 ubiquitin protein ligase
- naked mole-rat(101724821) MDM2 oncogene, E3 ubiquitin protein ligase
- sheep(101104979) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
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ELISA
Référence du produit
Description
Espèce(s)
Antibodies
Référence du produit
Description
Espèces réactives
Application
Anticorps anti-MDM2, clone IF2, clone IF2, from mouse,
Espèces réactives
human
Application
immunohistochemistry
western blot
western blot
Anti-MDM2 (Ab-2) Mouse mAb (2A10), liquid, clone 2A10, Calbiochem®,
Espèces réactives
human
Application
Anti-MDM2 Antibody, clone IF2, Alexa Fluor™ 488 Conjugate, clone IF2, from mouse, ALEXA FLUOR™ 488,
Espèces réactives
human
Application
immunocytochemistry
Anti-MDM2 Antibody, clone 2A10, clone 2A10, from mouse,
Espèces réactives
human
Application
immunoprecipitation (IP)
western blot
western blot
Monoclonal Anti-MDM2 antibody produced in mouse, ~2 mg/mL, clone MD-219, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
mouse
Application
ELISA
flow cytometry
immunocytochemistry
microarray
western blot
flow cytometry
immunocytochemistry
microarray
western blot