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Merck

HDAC8

histone deacetylase 8

Synonymes:
CDLS5, HD8, HDACL1, MRXS6, RPD3, WTS
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(55869) Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
  • Mouse(70315) histone deacetylase 8
  • Rat(363481) histone deacetylase 8
  • Zebrafish(406740) histone deacetylase 8
  • cow(540666) histone deacetylase 8
  • domestic cat(101096383) histone deacetylase 8
  • dog(480957) histone deacetylase 8
  • chicken(422182) histone deacetylase 8
  • domestic guinea pig(100721893) histone deacetylase 8
  • naked mole-rat(101697998) histone deacetylase 8
  • sheep(101110121) histone deacetylase 8

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Antibodies

Référence du produit
Description
Espèces réactives
Application
Monoclonal Anti-Histone Deacetylase 8 (HDAC8) antibody produced in mouse, 2.0-2.5 mg/mL, clone HDAC8-48, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
microarray

western blot
Monoclonal Anti-HDAC8 antibody produced in mouse, clone 2F4, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence

western blot
Anti-HDAC8 Antibody, serum, Upstate®,
Espèces réactives
human, mouse
Application
immunoprecipitation (IP)
western blot
Anti-HDAC8 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
Anti-phospho-HDAC8 (pSer39) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
Trichostatine A, ≥98% (HPLC), from Streptomyces sp.,
Espèce(s)
human, mouse, rat
Romidepsin, ≥98% (HPLC),
Espèce(s)
human
CI−994, ≥98% (HPLC), powder,
Espèce(s)
human

Kits

Référence du produit
Description
Espèce(s)
Histone Deacetylase 8 (HDAC8) Inhibitor Screening Kit, 100 assays in 96 well plates,
Espèce(s)
human, mouse

Proteins

Référence du produit
Description
Espèce(s)
HDAC-8 human, recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE),
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human HDAC8,
Espèce(s)
human
MISSION® esiRNA, targeting mouse Hdac8,
Espèce(s)
mouse