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Merck

HDAC6

histone deacetylase 6

Synonymes:
HD6
Espèce(s):
Human HDAC6 (10013), Mouse Hdac6 (15185), Rat Hdac6 (84581), Zebrafish hdac6 (565482), domestic cat HDAC6 (101084086), cow HDAC6 (513602), dog HDAC6 (480907), fruit fly HDAC6 (32461), domestic guinea pig Hdac6 (100717988), naked mole-rat Hdac6 (101708442)
ID UniProtKB:
Q9UBN7, O94975, Q6NT75, Q7L3E5, Q96CY0
ID du gène:
  • Human(10013) Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
  • Mouse(15185) histone deacetylase 6
  • Rat(84581) histone deacetylase 6
  • Zebrafish(565482) histone deacetylase 6
  • domestic cat(101084086) histone deacetylase 6
  • cow(513602) histone deacetylase 6
  • dog(480907) histone deacetylase 6
  • fruit fly(32461) CG6170 gene product from transcript CG6170-RA
  • domestic guinea pig(100717988) histone deacetylase 6
  • naked mole-rat(101708442) histone deacetylase 6
  • sheep(101109245) histone deacetylase 6

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Antibodies

Référence du produit
Description
Espèces réactives
Application
WH0010013M1
Monoclonal Anti-HDAC6 antibody produced in mouse, clone 1E2, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
western blot
AV31451
Anti-HDAC6 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
dog, horse, human, pig, rabbit
Application
ChIP
immunohistochemistry
western blot
HPA003714
Anti-HDAC6 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1,
Espèces réactives
human
Application
immunohistochemistry
07-732
Anti-HDAC6 Antibody, CT, Upstate®, from rabbit,
Espèces réactives
human, mouse
Application
immunoprecipitation (IP)
western blot
SAB4504190
Anti-phospho-HDAC6 (pSer22) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
SML0061
SAHA, ≥98% (HPLC),
Espèce(s)
human
T8552
Trichostatine A, ≥98% (HPLC), from Streptomyces sp.,
Espèce(s)
human, mouse, rat
SML1175
Romidepsin, ≥98% (HPLC),
Espèce(s)
human
C0621
CI−994, ≥98% (HPLC), powder,
Espèce(s)
human

Proteins

Référence du produit
Description
Espèce(s)
SRP0108
HDAC-6 human, recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE),
Espèce(s)
human
SRP0310
HDAC6 H216A human, recombinant, expressed in baculovirus infected Sf9 cells, ≥75% (SDS-PAGE),
Espèce(s)
human
SRP0311
HDAC6 H611A human, recombinant, expressed in baculovirus infected Sf9 cells, ≥79% (SDS-PAGE),
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
EMU055151
MISSION® esiRNA, targeting mouse Hdac6,
Espèce(s)
mouse
EHU054851
MISSION® esiRNA, targeting human HDAC6,
Espèce(s)
human