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Merck

HCN4

hyperpolarization activated cyclic nucleotide-gated potassium channel 4

Synonymes:
SSS2
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(10021) Summary: This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]
  • Mouse(330953) hyperpolarization-activated, cyclic nucleotide-gated K+ 4
  • Rat(59266) hyperpolarization activated cyclic nucleotide-gated potassium channel 4
  • domestic guinea pig(100717049) hyperpolarization activated cyclic nucleotide-gated potassium channel 4
  • naked mole-rat(101715130) hyperpolarization activated cyclic nucleotide-gated potassium channel 4
  • sheep(101117337) hyperpolarization activated cyclic nucleotide-gated potassium channel 4
  • Domestic Rabbit(100009452) hyperpolarization activated cyclic nucleotide-gated potassium channel 4
  • Zebrafish(557843) hyperpolarization activated cyclic nucleotide-gated potassium channel 4
  • cow(785689) hyperpolarization activated cyclic nucleotide-gated potassium channel 4
  • domestic cat(101090363) hyperpolarization activated cyclic nucleotide-gated potassium channel 4
  • dog(448794) hyperpolarization activated cyclic nucleotide-gated potassium channel 4
  • chicken(427478) hyperpolarization activated cyclic nucleotide-gated potassium channel 4

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Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-HCN4 Antibody, Chemicon®, from rabbit,
Espèces réactives
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-HCN4 Antibody, clone PG2-1A4, clone PG2-1A4, from rat,
Espèces réactives
mouse
Application
electron microscopy
immunofluorescence

immunohistochemistry

western blot
Monoclonal Anti-HCN4 antibody produced in mouse, clone S114-10, 1 mg/mL, purified immunoglobulin,
Espèces réactives
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry

western blot
Anti-HCN4, affinity isolated antibody,
Espèces réactives
human
Application
immunohistochemistry
Anti-HCN4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry

Small Molecule - Blocker

Référence du produit
Description
Espèce(s)
Ivabradine hydrochloride, ≥98% (HPLC),
Espèce(s)
human
Dronedarone hydrochloride, ≥98% (HPLC),
Espèce(s)
human
Dronedarone hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human
Dronedarone hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human