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Merck

DAG1

dystroglycan 1 (dystrophin-associated glycoprotein 1)

Synonymes:
156DAG, A3a, AGRNR, DAG, MDDGC7, MDDGC9
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(1605) Summary: Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.[provided by RefSeq, Apr 2010]
  • Mouse(13138) dystroglycan 1
  • Rat(114489) dystroglycan 1 (dystrophin-associated glycoprotein 1)
  • sheep(101103515) dystroglycan 1 (dystrophin-associated glycoprotein 1)
  • Domestic Rabbit(100009278) dystroglycan 1 (dystrophin-associated glycoprotein 1)
  • naked mole-rat(101714190) dystroglycan 1 (dystrophin-associated glycoprotein 1)
  • domestic guinea pig(100734382) dystroglycan 1 (dystrophin-associated glycoprotein 1)
  • Zebrafish(286829) dystroglycan 1
  • cow(281439) dystroglycan 1 (dystrophin-associated glycoprotein 1)
  • Horse(100053150) dystroglycan 1 (dystrophin-associated glycoprotein 1)
  • domestic cat(100174781) dystroglycan 1 (dystrophin-associated glycoprotein 1)
  • dog(476623) dystroglycan 1 (dystrophin-associated glycoprotein 1)
  • chicken(100049058) dystroglycan 1 (dystrophin-associated glycoprotein 1)
  • Thale Cress(825358) Dof zinc finger protein DOF3.7

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Antibodies

Référence du produit
Description
Espèces réactives
Application
Anticorps anti-α-dystroglycane, clone VIA4-1, culture supernatant, clone VIA4-1, Upstate®,
Espèces réactives
canine, guinea pig, human, mouse, rabbit, rat
Application
immunohistochemistry
western blot
Anti-α-Dystroglycan Antibody, ,
Espèces réactives
canine, guinea pig, human, mouse, rabbit, rat
Application
Anti-TROP2 Antibody, clone TrMab-29, ,
Espèces réactives
human
Application
flow cytometry
immunohistochemistry

western blot
Anti-α-Dystroglycan Antibody, clone VIA4-1 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
canine, guinea pig, human, mouse, rabbit, rat
Application
immunocytochemistry
immunohistochemistry

western blot
Anti-Cranin Antibody, aa572-604 of human sequence, clone 6C1, ascites fluid, clone 6C1, Chemicon®,
Espèces réactives
xenopus, chicken, human, mouse, rat, sheep
Application
ELISA
immunocytochemistry

immunohistochemistry

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting mouse Dag1,
Espèce(s)
mouse
MISSION® esiRNA, targeting human DAG1,
Espèce(s)
human