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Merck

CHUK

conserved helix-loop-helix ubiquitous kinase

Synonymes:
IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(1147) Summary: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]
  • Mouse(12675) conserved helix-loop-helix ubiquitous kinase
  • Rat(309361) conserved helix-loop-helix ubiquitous kinase
  • Zebrafish(393287) conserved helix-loop-helix ubiquitous kinase
  • cow(281073) conserved helix-loop-helix ubiquitous kinase
  • Horse(100070393) conserved helix-loop-helix ubiquitous kinase
  • dog(477796) conserved helix-loop-helix ubiquitous kinase
  • chicken(423669) conserved helix-loop-helix ubiquitous kinase
  • domestic cat(101095617) conserved helix-loop-helix ubiquitous kinase
  • sheep(101111143) conserved helix-loop-helix ubiquitous kinase
  • domestic guinea pig(100726357) conserved helix-loop-helix ubiquitous kinase
  • naked mole-rat(101719306) conserved helix-loop-helix ubiquitous kinase

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Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-Phospho-IKKα/β-S176/180 antibody produced in rabbit, ,
Espèces réactives
human
Application
western blot
Anti-CHUK (Ab-23) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-phospho-IKK-α/β (pSer180/181) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
western blot
Anti-p-IKKα/β-Ser176/180 Antibody, clone 2G2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
bovine, canine, feline, human, monkey, mouse, porcine, rat
Application
affinity binding assay
immunohistochemistry

inhibition assay

western blot
Anti-IKKa (p45) Antibody, clone 881H3, clone 881H3, from mouse,
Espèces réactives
human
Application
immunohistochemistry
immunoprecipitation (IP)

western blot

Proteins

Référence du produit
Description
Espèce(s)
IKKα Protein, active, 10 µg, Active, recombinant full-length human IKKα, containing an N-terminal GST-tag, for use in Kinase Assays.,
Espèce(s)
human
IKK α , active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting mouse Chuk,
Espèce(s)
mouse
MISSION® esiRNA, targeting human CHUK,
Espèce(s)
human

Small Molecule - Substrate

Référence du produit
Description
Espèce(s)
IKK Substrate Peptide, ,
Espèce(s)
human