ALOX5
arachidonate 5-lipoxygenase
Synonymes:
5-LO, 5-LOX, 5LPG, LOG5
Espèce(s):
Human ALOX5 (240), Mouse Alox5 (11689), Rat Alox5 (25290), Zebrafish alox5 (573013), chicken ALOX5 (423769), dog ALOX5 (477753), domestic cat ALOX5 (101097422), cow ALOX5 (404074), Horse ALOX5 (100062042), Zebrafish alox5 (567204) ...Plus
ID UniProtKB:
ID du gène:
- Human(240) Summary: This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
- Mouse(11689) arachidonate 5-lipoxygenase
- Rat(25290) arachidonate 5-lipoxygenase
- Zebrafish(573013) arachidonate 5-lipoxygenase
- chicken(423769) arachidonate 5-lipoxygenase
- dog(477753) arachidonate 5-lipoxygenase
- domestic cat(101097422) arachidonate 5-lipoxygenase
- cow(404074) arachidonate 5-lipoxygenase
- Horse(100062042) arachidonate 5-lipoxygenase
- Zebrafish(567204) arachidonate 5-lipoxygenase
- domestic guinea pig(100718093) arachidonate 5-lipoxygenase
- naked mole-rat(101700210) arachidonate 5-lipoxygenase
- sheep(101117390) arachidonate 5-lipoxygenase
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-ALOX5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-ALOX5 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human, mouse
Application
immunofluorescence
western blot
western blot
Anti-5′-Lipoxygenase Antibody, Chemicon®, from rabbit,
Espèces réactives
human, mouse, rabbit, rat
Application
ELISA
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Arachidonate 5 Lipoxygenase antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Phospho-ALOX5-S271 antibody produced in rabbit, ,
Espèces réactives
human
Application
western blot
Small Molecule - Inhibitor
Référence du produit
Description
Espèce(s)