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  • Mannich-Michael versus formal aza-Diels-Alder approaches to piperidine derivatives.

Mannich-Michael versus formal aza-Diels-Alder approaches to piperidine derivatives.

Organic & biomolecular chemistry (2011-03-11)
P Ricardo Girling, Takao Kiyoi, Andrew Whiting
ABSTRACT

A review into the aza-Diels-Alder reaction, mainly concentrating on literature examples that form piperidin-4-ones from the reaction of imines and electron rich dienes or enones, either through a Lewis acidic/Brønsted acid approach or through the use of an organocatalyst. This review questions whether the mechanism of the aza-Diels-Alder reaction is step wise as opposed to concerted when using oxygenated dienes.

MATERIALS
Product Number
Brand
Product Description

Supelco
Piperidine, analytical standard
Pricing and availability is not currently available.
Sigma-Aldrich
Piperidine, biotech. grade, ≥99.5%
Pricing and availability is not currently available.
Sigma-Aldrich
Piperidine, ≥99.5%, purified by redistillation
Pricing and availability is not currently available.
Sigma-Aldrich
Piperidine, ReagentPlus®, 99%
Pricing and availability is not currently available.