- [Vasopressin receptors: structure and stimulation by 1-deamino-arginine-vasotocin in rats].
[Vasopressin receptors: structure and stimulation by 1-deamino-arginine-vasotocin in rats].
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova (2007-09-14)
Iu V Natochin, T A Kanashkina, D Mordvintsev, E I Shakhmatova
PMID17850020
ABSTRACT
In experiments on non-anesthetized female Wistar rats, it has been shown that injection of 1-deamino-arginine-vasotocin (1dAVT) increases sodium excretion and solute-free water reabsorption. Antagonists of V1-receptors (OPC-31260, Otsuka Pharmaceutical Co., Ltd., Japan) eliminates the effect water reabsorption whereas antagonist of V1-receptors (OPC-21268, Otsuka Pharmaceutical Co., Ltd., Japan) decreases the 1dAVT-dependent increase of Na+ and water excretion. A model of V1-receptors an a supposed topography of their interaction with 1dAVT are constructed.
MATERIALS