Titanium dioxide nanotube modified implants: an animal study on bone formation.

Titanium dioxide nanotube modified implants: an animal study on bone formation.

Journal of nanoscience and nanotechnology (2013-07-19)

Kwi-Dug Yun, Sang-Won Park, Kwang-Min Lee, Hyun-Seung Kim, Mong-Sook Vang, Hong-So Yang, Jeong-Tae Koh, Seong-Soo Kang, Gye-Jeong Oh, Ga-Hyun Kim, Min-Kyung Ji, Gab-Woon Hwang, Hyun-Pil Lim

PMID23862419

ABSTRACT

This study examined the bone response to titanium dioxide nanotube modified implants. A total of 24 implants were placed in the femur of 4 beagles. Before placement, screw-shaped implants were classified into 3 groups; machined surface (group M), titanium dioxide nanotube modification of the machined surface (group MN) and titanium dioxide nanotube modification of the RBM surface (group RN). The texture morphology was observed via scanning electron microscopy. Animals were euthanized after 4 and 12 weeks of submerged healing and the histologic and histomorphometric analyses were performed. Groups MN and RN showed a significantly higher percentage of mineralized bone than that in group M (p < 0.05). The results of this in vivo study constitute significant evidence that the presence of the titanium dioxide nanotubes enhance osseointegration of implants.

MATERIALS

Product Number

Brand

Product Description

677469

Sigma-Aldrich

Titanium(IV) oxide, contains 1% Mn as dopant, nanopowder, <100 nm particle size (BET), ≥97%

14027

Sigma-Aldrich

Titanium(IV) oxide, puriss., meets analytical specification of Ph. Eur., BP, USP, 99-100.5%

14021

Sigma-Aldrich

Titanium(IV) oxide, ReagentPlus^®, ≥99%

718467

Sigma-Aldrich

Titanium(IV) oxide, nanopowder, 21 nm primary particle size (TEM), ≥99.5% trace metals basis

IRMM531A

Titanium, IRMM^®, certified reference material, 0.1 mm foil

348805

Sigma-Aldrich

Titanium, foil, thickness 0.5 mm, 99.99% trace metals basis

348864

Sigma-Aldrich

Titanium, wire, diam. 0.5 mm, 99.99% trace metals basis

267481

Sigma-Aldrich

Titanium, foil, thickness 0.25 mm, 99.99% trace metals basis

232033

Sigma-Aldrich

Titanium(IV) oxide, anatase, powder, 99.8% trace metals basis

268496

Sigma-Aldrich

Titanium, powder, −100 mesh, 99.7% trace metals basis

366994

Sigma-Aldrich

Titanium, powder, <45 μm avg. part. size, 99.98% trace metals basis

460397

Sigma-Aldrich

Titanium, foil, thickness 0.127 mm, ≥99.99% trace metals basis

267503

Sigma-Aldrich

Titanium, foil, thickness 0.25 mm, 99.7% trace metals basis

268526

Sigma-Aldrich

Titanium, sponge, 3-19 mm, 99.5% trace metals basis

248576

Sigma-Aldrich

Titanium(IV) oxide, anatase, powder, −325 mesh, ≥99% trace metals basis

637254

Sigma-Aldrich

Titanium(IV) oxide, anatase, nanopowder, <25 nm particle size, 99.7% trace metals basis

433667

Sigma-Aldrich

Titanium, evaporation slug, diam. × L 6.3 mm × 6.3 mm, ≥99.99% trace metals basis

767506

Sigma-Aldrich

Titanium, sputtering target, diam. × thickness 2.00 in. × 0.25 in., 99.995% trace metals basis

700347

Sigma-Aldrich

Titanium(IV) oxide, mixture of rutile and anatase, nanoparticles, <150 nm particle size (volume distribution, DLS), dispersion, 40 wt. % in H₂O, 99.5% trace metals basis

634662

Sigma-Aldrich

Titanium(IV) oxide, mixture of rutile and anatase, nanopowder, <100 nm particle size (BET), 99.5% trace metals basis

637262

Sigma-Aldrich

Titanium(IV) oxide, rutile, nanopowder, <100 nm particle size, 99.5% trace metals basis

635057

Sigma-Aldrich

Titanium(IV) oxide, rutile, <001>, (single crystal substrate), ≥99.9% trace metals basis, L × W × thickness 10 mm × 10 mm × 0.5 mm

IRMM531B

Titanium, IRMM^®, certified reference material, 0.5 mm foil

IRMM531C

Titanium, IRMM^®, certified reference material, 0.5 mm wire

266035

Sigma-Aldrich

Titanium, wire, diam. 1.0 mm, 99.99% trace metals basis