- Synthesis of (+)-patulolide C via an asymmetric hydroformylation/macrocyclization cascade.
Synthesis of (+)-patulolide C via an asymmetric hydroformylation/macrocyclization cascade.
Organic letters (2012-02-07)
Roberto M Risi, Steven D Burke
PMID22304535
ABSTRACT
A highly atom-economical total synthesis of (+)-patulolide C has been accomplished in three steps from the known (2R)-8-nonyn-2-ol in 49% overall yield and 93% de. A Rh(I)-catalyzed asymmetric hydroformylation (AHF)/ intramolecular Wittig olefination cascade was utilized to set the C4-hydroxyl stereochemistry and E-olefin geometry as well as form the macrolactone.
MATERIALS
Product Number
Brand
Product Description
Vinyl acetate, European Pharmacopoeia (EP) Reference Standard