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  • Synthesis of X(Y)-(EO)(n)-OCH₃ type heterobifunctional and X(Y)-(EO)(n)-Z type heterotrifunctional poly(ethylene glycol)s.

Synthesis of X(Y)-(EO)(n)-OCH₃ type heterobifunctional and X(Y)-(EO)(n)-Z type heterotrifunctional poly(ethylene glycol)s.

Bioconjugate chemistry (2011-02-11)
Zhongyu Li, Ying Chau
ABSTRACT

A synthetic route to prepare acetal-protected heterobifunctional poly(ethylene glycol), allyl(1-ethoxyethoxy)-PEG-OH (allyl(EE)-PEG-OH), was successfully established using a newly synthesized initiator, trimethylolpropane allyl (1-ethoxyethoxy) ether (TMPAEEE). Heterobifunctional allyl(OH)-mPEG and heterotrifunctional allyl(OH)-PEG-alkyne were obtained, respectively, after modification from this precursor polymer. The polymers were characterized by SEC, ¹H NMR, and MALDI-TOF mass spectroscopy. This approach is applicable for synthesizing a wide variety of X(Y)-(EO)(n)-OCH₃ type heterobifunctional and X(Y)-(EO)(n)-Z type heterotrifunctional PEGs.

MATERIALS
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Sigma-Aldrich
1,1,1-Tris(hydroxymethyl)propane, dist., ≥98.0% (GC)
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Sigma-Aldrich
1,1,1-Tris(hydroxymethyl)propane, 97%
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