SAB5700364

Anti-Phospho-p53-S46 antibody produced in rabbit

• Synonym(s): BCC7, BMFS5, LFS1, P53, TP53, TRP53, p53
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 23-43
• species reactivity: human
• concentration: 0.33 mg/ml
• technique(s): immunoprecipitation (IP): 1:50-1:100; western blot: 1:1000-1:2000
• UniProt accession no.: P04637
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer53/pSer46)
• Gene Information: human ... TP53(7157)

Description

General description

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).

Immunogen

A synthetic phosphorylated peptide around S46 of human p53 (NP_000537.3).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable