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Merck

HARS

histidyl-tRNA synthetase

Synonyms:
HRS, USH3B
Species:
UniProtKB ID:
Gene ID:
  • Human(3035) Summary: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
  • Mouse(15115) histidyl-tRNA synthetase
  • Rat(307492) histidyl-tRNA synthetase
  • sheep(101120491) histidyl-tRNA synthetase
  • Domestic Rabbit(100351394) histidyl-tRNA synthetase
  • domestic guinea pig(100729679) histidyl-tRNA synthetase
  • naked mole-rat(101712452) histidyl-tRNA synthetase
  • Zebrafish(447847) histidyl-tRNA synthetase
  • chicken(416132) histidyl-tRNA synthetase
  • cow(510937) histidyl-tRNA synthetase
  • domestic cat(101097371) histidyl-tRNA synthetase
  • dog(478034) histidyl-tRNA synthetase

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-HARS antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot
Anti-HARS antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot

Proteins

Product Number
Description
Species
Jo-1 human, recombinant, expressed in E. coli, solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Hars,
Species
mouse
MISSION® esiRNA, targeting human HARS,
Species
human