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A facile approach to the synthesis of chiral 2-substituted benzofurans.

The Journal of organic chemistry (2007-04-11)
Lidia De Luca, Giampaolo Giacomelli, Giammario Nieddu
ZUSAMMENFASSUNG

An effective route to chiral optically active 2-substituted benzofurans directly from carboxylic acids is reported. This procedure, which allows the preparation of alpha-alkyl-2-benzofuranmethanamines from N-protected alpha-amino acids without sensible racemization phenomena, proceeds in good yields under mild conditions with the help of microwave irradiation.

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Produktnummer
Marke
Produktbeschreibung

Sigma-Aldrich
(R)-(+)-α-Methoxy-α-trifluormethylphenylessigsäure, 99%