- Neural progenitor cells regulate microglia functions and activity.
Neural progenitor cells regulate microglia functions and activity.
Nature neuroscience (2012-10-23)
Kira I Mosher, Robert H Andres, Takeshi Fukuhara, Gregor Bieri, Maiko Hasegawa-Moriyama, Yingbo He, Raphael Guzman, Tony Wyss-Coray
PMID23086334
ZUSAMMENFASSUNG
We found mouse neural progenitor cells (NPCs) to have a secretory protein profile distinct from other brain cells and to modulate microglial activation, proliferation and phagocytosis. NPC-derived vascular endothelial growth factor was necessary and sufficient to exert at least some of these effects in mice. Thus, neural precursor cells may not only be shaped by microglia, but also regulate microglia functions and activity.